NONMEM Users Network Archive

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Parameter uncertainty

From: Fanny Gallais <gallais.fanny>
Date: Wed, 15 Feb 2017 11:55:23 +0100

Dear NM users,

I would like to perform a simulation (on R) incorporating parameter
uncertainty. For now I'm working on a simple PK model. Parameters were
estimated with NONMEM. I'm trying to figure out what is the best way to
assess parameter uncertainty. I've read about using the standard errors
reported by NONMEM and assume a normal distribution. The main problem is
this can lead to negative values. Another approach would be a more
computational non-parametric method like bootstrap. Do you know other
methods to assess parameter uncertainty?

Best regards

F. Gallais

Received on Wed Feb 15 2017 - 05:55:23 EST

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