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PhD Position in Clinical Pharmacology & Therapeutics (University College London, UK)

From: D'Agate, Salvatore <s.d'agate>
Date: Mon, 11 Dec 2017 14:12:09 +0000

Project title: Characterisation of PKPD relationships and dose rationale fo=
r anti-infective drugs for neglected tropical diseases.

Background: Neglected tropical diseases (NTDs) are a group of infectious di=
seases that affect an estimated one billion people in the world. Current tr=
eatments for most NTDs are suboptimal and new drugs are critically needed t=
o reduce disease burden.

While pharmacokinetic-pharmacodynamic concepts and advanced quantitative cl=
inical pharmacology principles have been integrated into the clinical devel=
opment of compounds across many therapeutic areas, human dose prediction an=
d early clinical evaluation of the efficacy and safety of candidate molecul=
es for NTDs remains empirical. Innovative approaches are required to enable=
 effective translation of nonclinical data, providing insight into the sele=
ction of rational combinations and optimised clinical trial designs.

A PhD position in translational pharmacology is available at the Clinical P=
harmacology & Therapeutics Group. The primary objective of the research wil=
l be to establish the pharmacokinetic-pharmacodynamic (PKPD) properties of =
drug candidates progressing into clinical development. Different approaches=
 will be evaluated for 1) the systematic translation of pharmacokinetic and=
 PKPD concepts from in vitro and in vivo systems to humans and 2) the optim=
isation of clinical study protocols for the evaluation of efficacy in tuber=
culosis, malaria, leishmaniasis and trypanosomiasis.

Required skills: In addition to enthusiasm, motivation and independent thin=
king, candidates must have working knowledge of pharmacokinetic-/pharmacody=
namic modelling, including some advanced statistical principles (nonlinear =
mixed effects modelling, Bayesian statistics, clinical trial simulations). =
Basic programming skills in R language, RStudio and NONMEM are essential.

Willingness to learn and integrate knowledge from across different therapeu=
tic areas. Behavioural attributes such as teamwork, accurate listening, str=
ategic thinking, along with good oral and written English language skills w=
ill be critical for the successful implementation of the project.

Candidates with a background in Medicine, Pharmaceutical Sciences, Biomedic=
al Sciences or Bioengineering are encouraged to apply.

Further information and applications can be submitted by email to Prof O De=
lla Pasqua (o.dellapasqua
Deadline for applications: 15th January 2018.

Kind regards,

Salvatore D'Agate
Clinical Pharmacology & Therapeutics
School of Life and Medical Sciences
University College London
E-mail: s.d'agate

Received on Mon Dec 11 2017 - 09:12:09 EST

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