From: Leonid Gibiansky <*lgibiansky*>

Date: Mon, 24 Apr 2017 12:00:00 -0400

CMT is important for dosing: it directs the dose to the appropriate

compartment (equation number).

It is a common misconception that CMT has to be related to observations.

It is relevant for observations only if F notation is used (and

therefore it is better to avoid using this notation).

For observations, one can set any compartment number (within the range

from 1 up to the number of equations in the model). Then, a separate

variable TYPE can be used, for example:

Y=A(2) + error ; for parent (TYPE=1)

IF(TYPE.EQ.2) Y = A(6)+A(7)+A(8) + error ; for metabolite (TYPE=2)

In this case, compartment number found on observation records can be

ignored. It will direct NONMEM to set F to the A(CMT) value, but if F is

not used, then it has no effect on the model or results.

Leonid

On 4/24/2017 11:26 AM, Fanny Gallais wrote:

*> Dear NMusers,
*

*>
*

*>
*

*>
*

*> I'm having trouble writing the code for my model. I have IV and IP
*

*> administrations data, that I would like to model simultaneously. We
*

*> found out that IP was best modeled by a first order absorption, using an
*

*> input compartment (DADT(1)=-KA*A(1)). At first, we used a CMT column in
*

*> the dataset to indicate for each dosing event if it is IV or IP. But
*

*> then, as we made the model more complicated, we realized that we
*

*> couldn't use a CMT column. We study the parent compound, as well as its
*

*> metabolite at the same time but the problem is we cannot put a
*

*> compartment number for the metabolite's observations. This is because,
*

*> given the model structure, the prediction for the metabolite
*

*> concentrations is a sum of 3 concentrations in 3 different compartments
*

*> (e.g. IPRED=A(6)+A(7)+A(8)). So we think that putting a compartment
*

*> number for the observation would be confusing for NONMEM. What do you
*

*> think? Do you see how we could model IV and IP simultaneously, without
*

*> using the CMT column ? or any other solution?
*

*>
*

*>
*

*>
*

*> Thank you for your help
*

*>
*

*> Fanny Gallais
*

Received on Mon Apr 24 2017 - 12:00:00 EDT

Date: Mon, 24 Apr 2017 12:00:00 -0400

CMT is important for dosing: it directs the dose to the appropriate

compartment (equation number).

It is a common misconception that CMT has to be related to observations.

It is relevant for observations only if F notation is used (and

therefore it is better to avoid using this notation).

For observations, one can set any compartment number (within the range

from 1 up to the number of equations in the model). Then, a separate

variable TYPE can be used, for example:

Y=A(2) + error ; for parent (TYPE=1)

IF(TYPE.EQ.2) Y = A(6)+A(7)+A(8) + error ; for metabolite (TYPE=2)

In this case, compartment number found on observation records can be

ignored. It will direct NONMEM to set F to the A(CMT) value, but if F is

not used, then it has no effect on the model or results.

Leonid

On 4/24/2017 11:26 AM, Fanny Gallais wrote:

Received on Mon Apr 24 2017 - 12:00:00 EDT