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Associate director, drug & disease progression Modeling at Sanofi

From: Christine.Veyrat-Follet
Date: Thu, 20 Oct 2016 14:21:50 +0000

Modeling and simulation (M&S) plays an increasingly important role in drug =
development at Sanofi. This position is for a modeling scientist, with part=
icular emphasis on disease progression modeling and mechanism-based approac=
hes. The scientist will primarily be responsible for developing and executi=
ng M&S strategies related to projects and integrating response to therapeut=
ics in disease progression modeling. Developing relationships with internal=
 and external collaborators will be essential to ensure that modeling meets=
 the strategic needs of the project teams. The primary focus will be on mod=
eling efforts to quantitatively integrate drug exposure, pathway biology, d=
isease physiology, and drug response with longitudinal disease course.

Major Duties & Responsibilities

* Directs overall pharmacometric project strategy and coordinates m=
odeling activities across projects. Designs, performs, and oversees pharmac=
ometric analyses using a variety of tools and approaches and in collaborati=
on with internal and external partners;

* Creates, advocates, and implements innovative program strategies =
while maintaining and enhancing technical and drug development expertise;

* Interacts with project teams and therapeutic areas to proactively=
 contribute expert input into model development, assuring rapid and effecti=
ve communication of results;

* Possesses in-depth understanding of biology relevant to model dev=

* Selects and collaborates with external partners/CROs;

* Maintains state-of-the art knowledge of relevant modeling approac=
hes and techniques.

Formal Education And Experience Required

* PhD with a track record of productivity in the areas of pharmacom=
etrics, disease progression modeling, computational biology, or related fie=
ld, as demonstrated by publications and presentations;

* Superb skills in collaboration and communicating both verbal and =
written technical and non-technical information, as appropriate;

* Modeling and computational experience, with excellent hands-on sc=
ientific computing and programming skills in a variety of computational too=
ls such as MATLAB, Monolix, NONMEM, Mathematica, R, PFIM, STAN, and excelle=
nt working knowledge of Linux and Windows environments.

Knowledge And Skills Required

* Modeling, pharmacometrics, and computational experience;

* Solid understanding of PK and quantitative pharmacology principle=

* Knowledge of biological pathways relevant to disease and applicat=
ion to model development (e.g., oncology, rare diseases);

* Excellent team work and superb skill in communicating information=

Location: Cambridge, MA USA
Position number: POS_75091432-0002JC

Sanofi US Services, Inc. and its U.S. affiliates are Equal Opportunity and =
Affirmative Action employers committed to a culturally diverse workforce. A=
ll qualified applicants will receive consideration for employment without r=
egard to race; color; creed; religion; national origin; age; ancestry; nati=
onality; marital, domestic partnership or civil union status; sex, gender, =
gender identity or expression; affectional or sexual orientation; disabilit=
y; veteran or military status or liability for military status; domestic vi=
olence victim status; atypical cellular or blood trait; genetic information=
 (including the refusal to submit to genetic testing) or any other characte=
ristic protected by law.

To learn more about this position, contact Christine Veyrat-Follet or Jeff =
Ming by email at Christine.veyrat-follet
es at

Received on Thu Oct 20 2016 - 10:21:50 EDT

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