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[NMusers] RE: No TABLE output with 1500 measurements per individual

From: <Jean-Marie.Martinez_at_sanofi.com>
Date: Wed, 23 Nov 2016 08:15:38 +0000

Dear NM-Users,

We are trying to model with NONMEM 7.3 (FOCE.I) a dataset containing one me=
asurement per minute for 68 individuals, for a total of 1440 measurements p=
er individual. The dataset is therefore composed of ~100,000 rows.
After having defined $SIZES adequately (LIM6 statement), the (successful) m=
inimization of the algorithm takes few minutes, without any warning or erro=
r messages.

The problem is that the TABLE output step is nearly impossible to obtain. E=
ven with the FIRSTONLY statement, no table can be obtained in a reasonable =
time period.

Trying to limit the table contents to ID & IPRED only does not solve the is=
sue.

We performed some additional tests with MSF files as input. When applying M=
SF to a dataset composed of only ONE individual at a time, the table takes =
24 hours to be generated.
This would therefore take 68 days (if time increases proportionally... ?) t=
o obtain PRED & IPRED for all individuals.

When implementing the model in an alternative commercial software, the tabl=
e is output in less than 20 minutes.

A solution would be to use MSF on a reduced dataset i.e., with a (randomly)=
 decreased number of measurements per individual, but we want to avoid this=
.
What other solution do we have ?

Can anyone provide some input on it ?

Thanks !

Jean-Marie Martinez
Modeling & Simulation Group
Sanofi Montpellier


Received on Wed Nov 23 2016 - 03:15:38 EST

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