# RE: No TABLE output with 1500 measurements per individual

From: Pieter Colin <Pieter.Colin>
Date: Wed, 23 Nov 2016 10:19:19 +0000

Dear Jean-Marie Martinez,

We've encountered a similar problem in the past.
Per my understanding calculation of the CWRES might be the problem here.
By adding WRESCHOL as option in your first table, after the "FILE="-state=
ment, this problem should be resolved.

Kind regards,

Pieter Colin
University Medical Center Groningen
Department of Anesthesiology (EB32)

From: owner-nmusers
Behalf Of Jean-Marie.Martinez
Sent: woensdag 23 november 2016 9:16
To: nmusers
Subject: [NMusers] RE: No TABLE output with 1500 measurements per individua=
l

Dear NM-Users,

We are trying to model with NONMEM 7.3 (FOCE.I) a dataset containing one me=
asurement per minute for 68 individuals, for a total of 1440 measurements p=
er individual. The dataset is therefore composed of ~100,000 rows.
After having defined \$SIZES adequately (LIM6 statement), the (successful) m=
inimization of the algorithm takes few minutes, without any warning or erro=
r messages.

The problem is that the TABLE output step is nearly impossible to obtain. E=
ven with the FIRSTONLY statement, no table can be obtained in a reasonable =
time period.

Trying to limit the table contents to ID & IPRED only does not solve the is=
sue.

We performed some additional tests with MSF files as input. When applying M=
SF to a dataset composed of only ONE individual at a time, the table takes =
24 hours to be generated.
This would therefore take 68 days (if time increases proportionally... ?) t=
o obtain PRED & IPRED for all individuals.

When implementing the model in an alternative commercial software, the tabl=
e is output in less than 20 minutes.

A solution would be to use MSF on a reduced dataset i.e., with a (randomly)=
decreased number of measurements per individual, but we want to avoid this=
.
What other solution do we have ?

Can anyone provide some input on it ?

Thanks !

Jean-Marie Martinez
Modeling & Simulation Group
Sanofi Montpellier

Received on Wed Nov 23 2016 - 05:19:19 EST

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