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Position for Pharmacometrician at Sanofi (Paris)

From: Laurent.Nguyen
Date: Mon, 14 Nov 2016 17:33:59 +0000

Pharmacometrician - Sanofi R&D - Location: Paris (France)
Sanofi R&D is looking for a highly motivated and creative individual to joi=
n its Modelling & Simulation group in Paris.
The individual will primarily be responsible for developing and executing P=
K/PD Modelling and Simulations (M&S) analyses to support drug development f=
rom discovery to late clinical stages in a variety of therapeutic areas for=
 both small and large molecules.
The candidate must have strong experience in PK/PD modelling and simulation=
 in the pharmaceutical industry and/or academia.

Main Responsibilities & Accountabilities:

  * Implements innovative quantitative methods to integrate data of pharm=
acokinetics, pharmacodynamics, biomarkers and clinical outcomes with inform=
ation of patient characteristics, knowledge of disease mechanisms and disea=
se progression to facilitate quantitative decision making in support to pro=
  * Elaborates and executes PK/PD M&S strategies in order to support mode=
l informed drug development in discovery programs, in strong collaboration =
with pre-clinical teams (DMPK, pharmacology, toxicology, biopharmacy) as we=
ll as with clinical and biostatistic teams.
  * Works and communicates interactively with people from diverse scienti=
fic backgrounds in a multi-disciplinary environment and interacts effective=
ly with project teams
  * Ensures quality of the study plan, protocols, reports, sections of re=
ports required for regulatory submissions to health authorities
  * Maintains state-of-the art knowledge of modelling techniques and work=
s in compliance with guidance of regulatory authorities.

Education and Experiences Required:

* PhD or equivalent degree in pharmaceutical sciences, mathematic=
s or similar disciplines with demonstrated expertise and a track record in =

* Excellent programming skills (e.g.: R, Matlab, SAS,...) and sol=
id hands-on experience (minimum of 3 years' experience) in Population PK/PD=
 modelling tools (e.g. NONMEM, Monolix, PFIM,..). Also practice in physiolo=
gy based pharmacokinetics modelling (e.g.: SimCYP, PK-sim MoBi, Gastro-Plus=
) would be an asset.

* In depth understanding of DMPK and pharmacology/ safety aspects=
 of drug discovery and clinical development, and of basic statistics.

* Excellent written and verbal communication skills, with success=
ful presentation capabilities

* At ease in working in a dynamic matrix organization and team pl=

* Proficient in spoken and written English and ability to communi=
cate in French is an asset

For further details on this position, please contact Laurent Nguyen by emai=
l: laurent.nguyen
or to apply to the position, please visit

Received on Mon Nov 14 2016 - 12:33:59 EST

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