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Re: $PRIOR with normal for OMEGA?

From: Martin Bergstrand <martin.bergstrand>
Date: Fri, 11 Nov 2016 08:32:05 +0100

Hi Mark,

Not sure about this but how about estimating THETAS scaling fix OMEGAs (e.g.=
 CL = THETA(1)*EXP(THETA(2)*ETA(1)) ; $OMEGA 1 fix)? Then you can implemen=
t the prior in the same way for random effect parameters as you do for fixed=
 effect parameters.

Ps. Probably not be compatible with MU-parameterization.

Best regards,
Martin Bergstrand, Ph.D.
Senior Consultant
Pharmetheus AB
+46(0)709 994 396
+46(0)18 513 328
U-A Science Park, Dag Hammarskjölds v. 52b
752 37 Uppsala, Sweden

Skickat från min iPhone
11 nov. 2016 kl. 04:57 skrev Mark Sale <msale

> Is it possible to use a normal prior for OMEGA? The default is inverse Wis=
hart, but I'd be interested in using Normal (insuring that it is positive de=
finite) Any ideas?
> thanks
> Mark Sale M.D.
> Vice President, Modeling and Simulation
> Nuventra Pharma Sciences, Inc.
> 2525 Meridian Parkway, Suite 280
> Durham, NC 27713
> Phone (919)-973-0383
> msale
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Received on Fri Nov 11 2016 - 02:32:05 EST

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