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[NMusers] Quantitative Pharmacology and Pharmacometrics Jobs Available - Merck

From: Wei Gao <weigao.pkpd_at_gmail.com>
Date: Wed, 11 May 2016 08:44:08 -0400

Dear all,

The Quantitative Pharmacology and Pharmacometrics (QP2) group at Merck
is now hiring at 3 levels: Senior Scientist, Associate Principal
Scientist, and Principal Scientist. Qualified candidates will be hired
at the level commensurate with their experience. We sponsor work visas
for qualified candidates. Please see below for job description and
forward to potential candidates. Thank you for your consideration.

Location: West Point, PA; Upper Gwynedd, PA; Kenilworth, NJ; Rahway,
NJ; Boston, MA.

To apply online, please visit http://www.merck.com/careers/

· Senior Scientist, R3 (QUA004740)
· Associate Principal Scientist, R4 (QUA004739)
· Principal Scientist, R5 (QUA004336)

●Senior Scientist
§ Description
Primary responsibilities of Senior Scientists in Quantitative
Pharmacology and Pharmacometrics (QP2) include serving as a
representative, or supporting the lead representative, for QP2 on drug
development teams; developing and executing PK/PD and Modeling &
Simulation (M&S) strategies; and applying functional area knowledge to
frame critical drug development questions for optimizing model-based
drug development. QP2 scientists apply PK/PD and M&S approaches to
design and evaluate clinical and preclinical study data, characterize
the kinetics of drug absorption and disposition, assess the dynamics
of drug effect, and inform dose selection and go/no-go decisions.
Senior Scientists are expected to develop a comprehensive
understanding of global regulatory expectations for small molecules
and biologics, including support for regulatory documents (INDs, CSRs,
CTDs), and agency interactions. The QP2 scientist is a quantitative
drug developer with a strong, integrated understanding of the
strategic elements of drug development (early through late), and leads
the combined efforts of QP2 & the wider Department of
Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM).
In addition to the responsibilities described above, Senior Scientists
demonstrate leadership, communication, and collaboration with QP2
leadership and key functional areas to create an aligned, quantitative
framework for impactful decision making on drug development teams.
Senior Scientists perform job duties in collaboration with more
experienced scientists, and are expected to develop expertise in one
or more scientific areas for QP2, including: translational and
clinical PK/PD analyses, disease state modeling, clinical trial
simulations, clinical outcomes modeling, comparator modeling,
absorption/biopharmaceutical modeling, adaptive design, clinical
utility indices, translation of biomarkers to clinical outcomes,
enrollment modeling, etc.
§ Qualification
A Doctorate OR a minimum 4 years with MS OR 6 with BS of experience in
a similar role in pharmaceutical drug development or academia, with a
record of increasing responsibility and independence. Educational
background in biopharmaceutics, pharmaceutical sciences,
pharmacometrics, chemical/biomedical engineering,
statistics/biostatistics, computational biology/chemistry or a related
field.

●Associate Principal Scientist
 § Description
Primary responsibilities of Associate Principal Scientists in
Quantitative Pharmacology and Pharmacometrics (QP2) include serving as
an expert representative for QP2 on drug development teams, developing
and executing PK/PD and Modeling & Simulation (M&S) strategies, and
applying functional area knowledge to frame critical drug development
questions for optimizing model-based drug development. QP2 Associate
Principal Scientists apply PK/PD and M&S approaches to design and
evaluate clinical and preclinical study data, characterize the
kinetics of drug absorption and disposition, assess the dynamics of
drug effect, and inform dose selection and go/no-go decisions.
Associate Principal Scientists also maintain a comprehensive
understanding of global regulatory expectations for small molecules
and biologics, including authoring regulatory documents (INDs, CSRs,
CTDs), and representing QP2 at regulatory meetings. The QP2 scientist
is a quantitative drug developer, with a strong, integrated
understanding of the strategic elements of drug development (early
through late), and leads the combined efforts of QP2 & the wider
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism
(PPDM).

In addition to the responsibilities described above, Associate
Principal Scientists demonstrate outstanding leadership,
communication, and collaboration with key functional areas to create
an aligned, quantitative framework for impactful decision making on
drug development teams. Associate Principal Scientists perform job
duties with independence and minimal supervision relative to less
experienced scientists, are capable of supporting or leading drug
development programs, and authoring strategic documents. Associate
Principal Scientists are expected to have or be developing expertise
in one or more scientific areas for QP2, including: translational and
clinical PK/PD analyses, disease state modeling, clinical trial
simulations, clinical outcomes modeling, comparator modeling,
absorption/biopharmaceutical modeling, adaptive design, clinical
utility indices, translation of biomarkers to clinical outcomes,
enrollment modeling, etc. They are also capable of leveraging this
expertise, in collaboration with other PPDM leaders and key functional
area partners, to provide scientific/strategic leadership and
influence on drug development teams.

§ Qualification
At least 3 years of experience in a similar role in pharmaceutical
drug development, with an excellent record of increasing
responsibility, independence, and demonstrated impact in driving drug
development decisions through application of model-based approaches.
PhD, PharmD, or other equivalent degree. Educational background in
biopharmaceutics, pharmaceutical sciences, pharmacometrics,
chemical/biomedical engineering, computational biology/chemistry or a
related field.

●Principal Scientist
§ Description
Primary responsibilities of Principal Scientists in Quantitative
Pharmacology and Pharmacometrics (QP2) include serving as an expert
representative for QP2 on drug development teams, developing and
executing PK/PD and Modeling & Simulation (M&S) strategies, and
applying functional area knowledge to frame critical drug development
questions for optimizing model-based drug development.

QP2 Principal Scientists apply PK/PD and M&S approaches to design and
evaluate clinical and preclinical study data, characterize the
kinetics of drug absorption and disposition, assess the dynamics of
drug effect, and inform dose selection and go/no-go decisions.
Principal Scientists also maintain a comprehensive understanding of
global regulatory expectations for small molecules and biologics,
including authoring regulatory documents (INDs, CSRs, CTDs), and
representing QP2 at regulatory meetings. The QP2 scientist is a
quantitative drug developer, with a strong, integrated understanding
of the strategic elements of drug development (early through late),
and leads the combined efforts of QP2 & the wider Department of
Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM).

In addition to the responsibilities described above, Principal
Scientists demonstrate outstanding leadership, communication, and
collaboration with key functional areas to create an aligned,
quantitative framework for impactful decision making on drug
development teams. Principal Scientists perform job duties with a high
degree of independence relative to less experienced scientists, are
capable of supporting and/or leading more complex drug development
programs, author strategic documents, and have responsibility for
scientific oversight of staff across the group. Principal Scientists
are expected to have or be developing expertise in several key
scientific areas for QP2, including: translational and clinical PK/PD
analyses, clinical trial simulations, disease state modeling, clinical
outcomes modeling, comparator modeling, absorption/biopharmaceutical
modeling, adaptive design, clinical utility indices, translation of
biomarkers to clinical outcomes, enrollment modeling, etc. They are
also capable of leveraging this expertise, in collaboration with other
PPDM leaders and key functional area partners, to provide
scientific/strategic leadership and influence within QP2 as well as
outside the department.

§ Qualification
A minimum of 7 years of experience in a similar role in pharmaceutical
drug development, with an exemplary record of increasing
responsibility, independence, and demonstrated impact in driving drug
development decisions through application of model-based approaches.
PhD with a concentration in biopharmaceutics, pharmaceutical sciences,
pharmacometrics, chemical/biomedical engineering, computational
biology/chemistry or a related field.

Merck Culture: Merck & Co., Inc. Kenilworth, NJ USA, is known as MSD
outside the United States and Canada. Our business is preserving and
improving human life. We also work to improve animal health. All of
our actions must be measured by our success in achieving these goals.
We value, above all, our ability to serve everyone who can benefit
from the appropriate use of our products and services, thereby
providing lasting consumer satisfaction. Today, we are building a new
kind of healthcare company – one that is ready to help create a
healthier future for all of us. Our ability to excel depends on the
integrity, knowledge, imagination, skill, diversity and teamwork of an
individual like you. To this end, we strive to create an environment
of mutual respect, encouragement and teamwork. As part of our global
team, you’ll have the opportunity to collaborate with talented and
dedicated colleagues while developing and expanding your career.
Received on Wed May 11 2016 - 08:44:08 EDT

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