NONMEM Users Network Archive

Hosted by Cognigen

Pharmacometric Statistics Workshop

From: adrian.dunne
Date: Mon, 6 Jun 2016 14:35:33 +0100

There are still some places available for the following workshop.




Registration is now open for this 3 day workshop to be held from

20th to 22nd September 2016 in Dublin, Ireland.


The aim of this workshop is to give pharmacometricians a good

understanding of the statistical concepts upon which their work is

based and which are of great importance in everything they do. The

emphasis will be on concepts with an absolute minimum of mathematical

details. Attendees need only have studied statistics at foundation

level prior to taking this course. The topics covered include;


1) Why use statistics?


2) Probability and statistical inference.


3) Laws of probability and Bayes theorem.


4) Univariate probability distributions - Expected value and variance.


5) Multivariate probability distributions - joint, marginal and

   conditional distributions. The covariance matrix. Independence and

   conditional independence.


6) Modelling, estimation, estimators, sampling distributions, bias,

   efficiency, standard error and mean squared error. Consistency.


7) Point and interval estimators. Confidence intervals.


8) Hypothesis testing, null and alternative hypotheses. P-value, Type

   I and type II errors and power.


9) Likelihood inference, maximum likelihood estimator (MLE),

   likelihood ratio. BQL and censored data.


10) Minimal sufficiency and invariance of the likelihood ratio and the MLE.


11) The score function, hessian, Fisher information, quadratic

    approximation and standard error.


12) Wald confidence intervals and hypothesis tests.


13) Likelihood ratio tests.


14) Profile likelihood, nested models.


15) Model selection, Akaike and Bayesian Information Criteria (AIC & BIC).


16) Maximising the likelihood, Newton's method.


17) Mixed effects models.


18) Estimation of the fixed effects, conditional independence, prior

    and posterior distributions.


19) Approximating the integrals, Laplace and first order (FO & FOCE)

    approximations, numerical quadrature.


20) The Expectation Maximisation (EM) algorithm.


21) MU-Modelling, Iterative Two Stage (ITS)


22) Monte Carlo EM (MCEM), Importance Sampling, Direct Sampling, SAEM,

    Markov Chain Monte Carlo (MCMC).


23) Estimating the random effects, empirical bayes estimates (EBE)

    and shrinkage.


24) Asymptotic properties of the MLE, efficiency, the Cramer-Rao Lower

    Bound (CRLB), consistency, normality.


25) Robustness of the MLE, the Kullback-Liebler distance. Quasi

likelihood and the robust or sandwich variance estimator.



For further details and to register please go to our website



Early registration is advised because the number of places is limited.



Adrian Dunne PhD,

6 The Avenue, Woodpark, Ballinteer, Dublin 16, Ireland

Tel: +353-(0)1-2986843

Mob: +353-(0)860407504

E-mail: adrian.dunne


(image/jpeg attachment: image001.jpg)

Received on Mon Jun 06 2016 - 09:35:33 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: