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Re: [NMusers] Laplacian, BQL and initial estimates

From: Mark Sale <msale_at_nuventra.com>
Date: Mon, 18 Jul 2016 16:22:03 +0000

thanks Bob


Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
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________________________________
From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Sent: Monday, July 18, 2016 12:19:22 PM
To: Mark Sale; Bill Denney; nmusers_at_globomaxnm.com
Subject: RE: [NMusers] Laplacian, BQL and initial estimates

Mark:
I have looked at the initial theta evaluation which occurs when a lower and=
 upper bound are supplied, and no initial value (such as (0.001,,100.0), an=
d it seems that this method will only do a search using a First order objec=
tive function evaluation. I will see if it can be expanded to FOCE/FOCEI/La=
place for NONMEM 7.4.

Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Mark Sale
Sent: Sunday, July 17, 2016 2:00 PM
To: Bill Denney; nmusers_at_globomaxnm.com
Subject: Re: [NMusers] Laplacian, BQL and initial estimates


pretty standard $EST I think
$ESTIMATION METH=1 NUMERICAL SLOW LAPLACIAN INTER NOTHETABOUNDTEST NOOMEG=
ABOUNDTEST
 MAXEVAL=9999 PRINT=1 NOABORT MSFO=MSF1


and just 1.





Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
CONFIDENTIALITY NOTICE The information in this transmittal (including attac=
hments, if any) may be privileged and confidential and is intended only for=
 the recipient(s) listed above. Any review, use, disclosure, distribution o=
r copying of this transmittal, in any form, is prohibited except by or on b=
ehalf of the intended recipient(s). If you have received this transmittal i=
n error, please notify me immediately by reply email and destroy all copies=
 of the transmittal.


________________________________
From: Bill Denney <wdenney_at_humanpredictions.com>
Sent: Sunday, July 17, 2016 4:54:05 PM
To: Mark Sale; nmusers_at_globomaxnm.com
Subject: Re: [NMusers] Laplacian, BQL and initial estimates


Hi Mark,



Might you have more than one $EST step where Laplacian is not used in one o=
f them? And, can you share your $EST step options?



Thanks,



Bill

On 7/17/2016 4:28 PM, Mark Sale wrote:

Question:

NONMEM has a function to run a grid search to obtain initial estimates for =
THETA. But, when I try to do this with BQL data/Laplacian I get this run ti=
me error message:
0PROGRAM TERMINATED BY OBJ
 WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13
 WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED


It seems the Laplacian isn't used for the grid search for initial estimates=
 (even though specified in $EST).

any ideas?





Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
msale_at_nuventra.com<msale_at_kinetigen.com>
CONFIDENTIALITY NOTICE The information in this transmittal (including attac=
hments, if any) may be privileged and confidential and is intended only for=
 the recipient(s) listed above. Any review, use, disclosure, distribution o=
r copying of this transmittal, in any form, is prohibited except by or on b=
ehalf of the intended recipient(s). If you have received this transmittal i=
n error, please notify me immediately by reply email and destroy all copies=
 of the transmittal.


________________________________
<https://protect-eu.mimecast.com/s/E52oBu0A5VWC1>[Image removed by sender. =
Human Predictions Logo]<https://protect-eu.mimecast.com/s/E52oBu=
0A5VWC1><https://protect-eu.mimecast.com/s/E52oBu0A5VWC1>William S. Denney,=
 PhD
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com<mailto:wdenney_at_humanpredictions.com>


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Received on Mon Jul 18 2016 - 12:22:03 EDT

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