NONMEM Users Network Archive

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Re: [NMusers] Laplacian, BQL and initial estimates

From: Bill Denney <wdenney_at_humanpredictions.com>
Date: Sun, 17 Jul 2016 16:54:05 -0400

Hi Mark,


Might you have more than one $EST step where Laplacian is not used in
one of them? And, can you share your $EST step options?


Thanks,


Bill


On 7/17/2016 4:28 PM, Mark Sale wrote:
>
> Question:
>
> NONMEM has a function to run a grid search to obtain initial estimates
> for THETA. But, when I try to do this with BQL data/Laplacian I get
> this run time error message:
>
> 0PROGRAM TERMINATED BY OBJ
> WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13
> WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED
>
> It seems the Laplacian isn't used for the grid search for initial
> estimates (even though specified in $EST).
>
> any ideas?
>
>
>
>
> Mark Sale M.D.
>
> Vice President, Modeling and Simulation
>
> Nuventra Pharma Sciences, Inc.
> 2525 Meridian Parkway, Suite 280
> Durham, NC 27713
>
> Phone (919)-973-0383
>
> msale_at_nuventra.com <msale_at_kinetigen.com>
>
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------------------------------------------------------------------------
Human Predictions Logo <http://www.humanpredictions.com>*William S.
Denney, PhD*
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com

Received on Sun Jul 17 2016 - 16:54:05 EDT

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