NONMEM Users Network Archive

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model of error, linearisation, additive error, and VPC

From: Pavel Belo <nonmem>
Date: Fri, 29 Jan 2016 16:47:25 -0500 (EST)

Hello NONMEM Users,

When I tried to print log-scaled VPC, there was an error message about
values.  It can be caused by an additive error and/or linearization of=
error model when NONMEM transforms 
Y  = F*DEXP(ERR(1)*SD1)  into Y  =
F+ F*ERR(1)*SD1.  The error is inflated at small concentrations a=
removing the additive term
is not an option in my case.  
Is there an easy way to
solve it?  It can be something like Y  = F**GAMMA*DEXP(ERR(1)*S=
D1)  or
Y  = F+ F*ERR(1)*SD1 + F**GAMMA*ERR(2)*SD2, where GAMMA<1.=




Received on Fri Jan 29 2016 - 16:47:25 EST

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