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Systems Pharmacology/PBPK Workshop with PK-Sim and MoBi at PAGE meeting

From: Donato Teutonico <donato.teutonico>
Date: Thu, 25 Feb 2016 10:15:44 +0000

Physiologically based modeling of intrinsic and extrinsic factors influenci=
ng pharmacokinetics
A Systems Pharmacology Workshop by Bayer using PK-Sim® and MoBi®

Monday, June 6th, Lisbon, Portugal

Modeling and simulation scientists in drug development are faced with ever =
growing challenges regarding flexibility, accuracy and applicability of mod=
els to support an increasing number of projects. Moreover, clinical program=
s can benefit from more detailed mechanistic models as knowledge-driven dru=
g development is taken to the next level by dedicated software tools for Qu=
antitative Systems Pharmacology (QSP) applications. Such tools can provide =
a valuable means for addressing these challenges in a flexible and versatil=
e manner and are supported by regulatory guidance such as the FDA Guidance =
for industry - Drug-Drug Interaction studies.

In this one-day workshop, Bayer Technology Services (BTS) will focus on tea=
ching and demonstrating how to build fully integrated systems pharmacology=
 models using BTS' Software Suite with PK-Sim® and MoBi®, a QSP modelin=
g & simulation platform applicable for a wide number of use cases. These in=
clude classic physiologically based pharmacokinetic (PBPK) approaches such =
as species extrapolation, translating between (special) populations and dru=
g-drug interaction (DDI) prediction as well as more complex QSP models for =
different indications.

Attendees will learn how to easily deal with challenging mechanistic modeli=
ng tasks focusing on pharmacokinetics and pharmacodynamics, exemplified by =
several real-life use cases. These will be introduced with in-depth lecture=
s followed by dedicated hands-on training sessions. Particular attention is=
 given to questions communicated by attendees, we will ensure that sufficie=
nt room will be given for detailed and lively discussions.

Hands-on sessions will, among others, cover the following topics:

- how to develop and set-up PBPK models with PK-Sim®,

- how to scale an existing model to different populations (e.g. young=
, elderly, renally impaired, or hepatically impaired populations)

- how to extend and couple models to investigate drug-drug interactio=
ns, e.g. via a common transporter using MoBi®

- how automatic tracking and documentation functionalities available =
in the software can be applied for better overview and transparency

We are looking forward to meeting you at the workshop and are happy to answ=
er questions regarding registration and organization: info

Additional information:
The workshop will be free of charge, the registration form is available at =
the following link:

Best regards,

Donato Teutonico
Systems Pharmacology CV

Bayer Technology Services GmbH
BTS-TD-ET-SPC, Systems Pharmacology CV
Building B106, 210
51368 Leverkusen, Germany

Tel: +49 214 30 55352
Mobile: +49 173 78 06651
E-mail: donato.teutonico

Geschäftsführung: Armin Knors, Geschäftsführer
Vorsitzender des Aufsichtsrats: Hartmut Klusik
Sitz der Gesellschaft: Leverkusen | Amtsgericht Köln, HRB 49896

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Received on Thu Feb 25 2016 - 05:15:44 EST

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