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Post doc opportunity at AstraZeneca

From: Cheung, Amy <Amy.Cheung>
Date: Wed, 17 Feb 2016 07:34:20 +0000

Post Doctoral Opportunity - Drug Safety Metabolism
* Reference Number: PostDoc 112
* Career Area: Drug Safety Metabolism IMED<http://jobs.astrazeneca.=
* United Kingdom<
Description Development of a haematopoiesis model that can be used for tran=
slational clinical predictions of bone marrow toxicity. We're currently loo=
king for talented scientists to join our innovative academic-style Postdoc,=
 on a 2 year Fixed Term Contract. From our centre in Cambridge, UK, you'll =
be in a global pharmaceutical environment, contributing to live projects ri=
ght from the start. You'll take part in a comprehensive training programme,=
 including a focus on drug discovery and development, given access to our e=
xisting Postdoctoral research, and encouraged to pursue your own independen=
t research in cutting edge laboratories. It's a newly expanding programme s=
panning a range of therapeutic areas across a wide range of disciplines.
What's more, you'll have the support of a leading academic advisor, who'll =
provide you with the guidance and knowledge you need to develop your career=
. This is an exciting area that hasn't been explored to its full potential,=
 making this an opportunity to make a real difference to the future of medi=
cal science.

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that =
focuses on the discovery, development and commercialisation of prescription=
 medicines for some of the world's most serious diseases. But we're more th=
an one of the world's leading pharmaceutical companies. At AstraZeneca, we'=
re proud to have a unique workplace culture that inspires innovation and co=
llaboration. Here, employees are empowered to express diverse perspectives =
- and are made to feel valued, energised and rewarded for their ideas and c=

Therapy Area
One of the greatest challenges when discovering and formulating effective m=
edicines lies in mapping their pharmacokinetic properties - how they'll rea=
ct within the human body. Here, you'll ensure our drug products are safe fo=
r clinical trials, and ultimately safe to deliver as novel treatments to ou=
r patients. To make that happen, you'll be working with truly cutting-edge =
in silico, in vivo, cellular and molecular technologies to push the boundar=
ies of predictive science.

Role Description
If you're keen to help improve effectiveness of anti-cancer therapies this =
Post Doc will give you the opportunity to investigate how stem cell biology=
 gives rise to regeneration of adult tissues and develop mechanistic unders=
tanding of Oncology agents' toxicity.
As a Postdoctoral Scientist in DSM it's essential that you have:
* A PhD in relevant discipline, such as Biological Engineering, Sys=
tems Biology, Biology, Maths, Engineering or Physics
* Experience with model building software like Matlab or Berkeley M=
* A proven record of publication in reputable scientific journals
* Hands-on experience with quantitative techniques like systems bio=
logy or systems pharmacology
* The confidence to creatively explore alternative modelling approa=
The following skills and qualifications are desirable:
* Knowledge of cancer biology, including DNA damage response and ap=
optosis pathways
* A firm understanding of the haematopoiesis process
* Experience of modelling cell populations such as stem cells, cell=
ular differentiation or cell cycle
* Expertise in drug toxicology, immunological techniques or flow cy=
As a Postdoctoral Scientist in DSM you will:
* Quantify the impact of Oncology drugs and drug combinations on bo=
ne marrow cell populations and assess how this impacts blood cell count
* Optimise oncology therapies to translate preclinical findings int=
o human models
* Collaborate with other experts in a wide range of areas and field=
Additional information:
To apply for this position, please click the apply link.
AstraZeneca welcomes applications from all sections of the community.
An Equal Opportunity Employer. All qualified applicants will receive consid=
eration for employment without regard to race, colour, religion, sex, natio=
nal origin, or protected veteran status and will not be discriminated again=
st on the basis of disability.
This is a 2 year Fixed Term Contract opportunity with a competitive salary =
on offer.

Closing Date: Midnight - 8th April 2016



AstraZeneca UK Limited is a company incorporated in England and Wales with =
registered number: 03674842 and a registered office at 2 Kingdom Street, Lo=
ndon, W2 6BD.

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Received on Wed Feb 17 2016 - 02:34:20 EST

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