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[NMusers] RE: Generating TAD with ADDL dosing format

From: de Almeida, Camila <Camila.deAlmeida_at_astrazeneca.com>
Date: Tue, 20 Dec 2016 14:20:10 +0000

Thanks Maria and all the others for the quick reply,

I don’t have a lag time, also the number of additional doses vary between individuals, so this code below from Maria seems to work wonderfully.

I am using psn to run the vpc plots and although I need to adjust some of the input parameters it seems to be doing something in the direction I need, so thank you very much for your input.

Camila.

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Pitsiu, Maria
Sent: 20 December 2016 13:14
To: nmusers_at_globomaxnm.com
Subject: [NMusers] RE: Generating TAD with ADDL dosing format

Hi Camila

If you don’t have a lag time, use the following:
$PK
IF(NEWIND.LT.2) THEN
IFL=0
TAD=0.0
ENDIF
IF(EVID.EQ.1.OR.EVID.EQ.4)DTIME=TIME
 IF(DOSTIM.NE.0.)DTIME=DOSTIM ; non-event dose times

TAD=TIME-DTIME

If you have a lag time, use:
IF(NEWIND.LT.2) THEN
TAD=0.0
DTIME=1.0E+06
ENDIF

IF(DOSTIM>0.0) DTIME=DOSTIM -ALAG1 ; dostim is non-zero on additional doses (ADDL/II), no delay in doses
IF(AMT>0.AND.DOSTIM==0.0) DTIME=TIME ; for all dose events scheduled explcitly in the data record, no delay
TAD=TIME-DTIME

I hope this helps

Maria


Maria Pitsiu ICON Plc PK M&S 7122 3652 (internal) +44 162 849 3652 (external)

From: owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com> [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of de Almeida, Camila
Sent: 20 December 2016 13:46
To: nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>
Subject: [NMusers] Generating TAD with ADDL dosing format

Hello,

I was wondering if I could get some guidance from this great group. My issue is primarily with some diagnostic analysis, but this is taking me back to an old NONMEM problem.

My aim is to run a VPC on a model I implemented, and if possible change the idv to TAD instead of TIME. The reason for that is the VPC graph based on TIME looks dreadful as the data is sparse and from different studies of different lengths.

I’m having issues generating the TAD output column from my NONMEM run. I naively assumed I could easily do that, but looking at the NONMEM archives it seems this gets tricky when your dosing events are written using ADDL. Has anyone ever managed to find a solution for this? And if not, is there an alternative way to run the VCP on TAD, do we really need to get this column from NONMEM’s output?

Thanks all,

Camila de Almeida, PhD
PKPD Scientist,
Modelling & Simulation, IMED Oncology DMPK
________________________________________________________________________________
AstraZeneca UK Limited
R&D, Innovative Medicines

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AstraZeneca UK Limited is a company incorporated in England and Wales with registered number:03674842 and its registered office at 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA.

This e-mail and its attachments are intended for the above named recipient only and may contain confidential and privileged information. If they have come to you in error, you must not copy or show them to anyone; instead, please reply to this e-mail, highlighting the error to the sender and then immediately delete the message. For information about how AstraZeneca UK Limited and its affiliates may process information, personal data and monitor communications, please see our privacy notice at www.astrazeneca.com<https://www.astrazeneca.com>
Received on Tue Dec 20 2016 - 09:20:10 EST

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