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Re: [NMusers] Generating TAD with ADDL dosing format

From: Alejandro Pérez Pitarch <alejandroperezpitarch_at_gmail.com>
Date: Tue, 20 Dec 2016 13:25:00 +0100

Hi Camila,

I had this same issue some time ago and, given that in my dataset all
Interdose Intervals (II) were constant for all the patients, I used the
following R function to get a TAD column (IDV in my dataset):

InsertIDV<-function(runn,ii){ # runn is the
run number: for run03 runn="03"; ii is the inter-dose interval
  sdtab<-get(paste("sdtab",runn,sep=""))
  last<-floor(sdtab$TIME/ii)*ii # defines
time at which last dose was administrated
  sdtab$IDV<-sdtab$TIME-last
  assign(paste("sdtab",runn,sep=""),sdtab,envir = .GlobalEnv)
}

I hope this script is useful for your problem.

Regards,


Alejandro Pérez Pitarch
Pharmacy Department
University Clinical Hospital of Valencia







2016-12-20 12:45 GMT+01:00 de Almeida, Camila <
Camila.deAlmeida_at_astrazeneca.com>:

> Hello,
>
>
>
> I was wondering if I could get some guidance from this great group. My
> issue is primarily with some diagnostic analysis, but this is taking me
> back to an old NONMEM problem.
>
>
>
> My aim is to run a VPC on a model I implemented, and if possible change
> the idv to TAD instead of TIME. The reason for that is the VPC graph base=
d
> on TIME looks dreadful as the data is sparse and from different studies o=
f
> different lengths.
>
>
>
> I’m having issues generating the TAD output column from my NONMEM=
 run. I
> naively assumed I could easily do that, but looking at the NONMEM archive=
s
> it seems this gets tricky when your dosing events are written using ADDL.
> Has anyone ever managed to find a solution for this? And if not, is there
> an alternative way to run the VCP on TAD, do we really need to get this
> column from NONMEM’s output?
>
>
>
> Thanks all,
>
>
>
> *Camila de Almeida, PhD*
>
> PKPD Scientist,
>
> *Modelling & Simulation, IMED Oncology DMPK*
>
>
> *________________________________________________________________________=
________*
>
> *AstraZeneca UK Limited*
>
> *R&D, Innovative Medicines*
>
>
>
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>
>
>
>
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>
>
>
>
>
>
>
>
>
>
>
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Received on Tue Dec 20 2016 - 07:25:00 EST

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