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RE: Generating TAD with ADDL dosing format

From: Tim Bergsma <Tim.Bergsma>
Date: Tue, 20 Dec 2016 13:32:50 +0000

Hi Camila.

If you have access to R, consider the github package "tad" identified below=
. It supports calculation of TAD as a column in your dataset, explicitly c=
onsidering ADDL. Let me know if you have issues installing or operating. =
The following worked for me.




Tim Bergsma, PhD
Associate Director
Certara Strategic Consulting
m. 860.930.9931

From: owner-nmusers
 Behalf Of de Almeida, Camila
Sent: Tuesday, December 20, 2016 6:46 AM
To: nmusers
Subject: [NMusers] Generating TAD with ADDL dosing format


I was wondering if I could get some guidance from this great group. My issu=
e is primarily with some diagnostic analysis, but this is taking me back to=
 an old NONMEM problem.

My aim is to run a VPC on a model I implemented, and if possible change the=
 idv to TAD instead of TIME. The reason for that is the VPC graph based on =
TIME looks dreadful as the data is sparse and from different studies of dif=
ferent lengths.

I'm having issues generating the TAD output column from my NONMEM run. I na=
ively assumed I could easily do that, but looking at the NONMEM archives it=
 seems this gets tricky when your dosing events are written using ADDL. Has=
 anyone ever managed to find a solution for this? And if not, is there an a=
lternative way to run the VCP on TAD, do we really need to get this column =
from NONMEM's output?

Thanks all,

Camila de Almeida, PhD
PKPD Scientist,
Modelling & Simulation, IMED Oncology DMPK
AstraZeneca UK Limited
R&D, Innovative Medicines

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Received on Tue Dec 20 2016 - 08:32:50 EST

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