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RE: Generating TAD with ADDL dosing format

From: Andrzej Bienczak <andrzej.bienczak>
Date: Tue, 20 Dec 2016 14:31:27 +0200



I'm not sure what data you're analysing and what your dosage schedules and
sampling are but if ADDL is the same for each patient you could create a new
variable (TVPC) and simply deduct that additional dosing history from your
cumulative time from when you restarted the system (EVID=3 or 4). You code
it simply as:


TVPC=TIME- sum of all ADDLs


So if you have 3 additional doses, each at a 24h interval it would look




Then you can plot your VPC with TVPC as idv.





Andrzej Bienczak

MSc, MPharm, DiplPharm

Pharmacometrics Group

Division of Clinical Pharmacology

Department of Medicine

University of Cape Town


K45 Old Main Building

Groote Schuur Hospital

Observatory, Cape Town

7925 South Africa

phone: +27 21 650 4861

mobile: +27 839 842 675

email: andrzej.bienczak





From: owner-nmusers
Behalf Of de Almeida, Camila
Sent: 20 December 2016 01:46 PM
To: nmusers
Subject: [NMusers] Generating TAD with ADDL dosing format




I was wondering if I could get some guidance from this great group. My issue
is primarily with some diagnostic analysis, but this is taking me back to an
old NONMEM problem.


My aim is to run a VPC on a model I implemented, and if possible change the
idv to TAD instead of TIME. The reason for that is the VPC graph based on
TIME looks dreadful as the data is sparse and from different studies of
different lengths.


I'm having issues generating the TAD output column from my NONMEM run. I
naively assumed I could easily do that, but looking at the NONMEM archives
it seems this gets tricky when your dosing events are written using ADDL.
Has anyone ever managed to find a solution for this? And if not, is there an
alternative way to run the VCP on TAD, do we really need to get this column
from NONMEM's output?


Thanks all,


Camila de Almeida, PhD

PKPD Scientist,

Modelling & Simulation, IMED Oncology DMPK


AstraZeneca UK Limited

R&D, Innovative Medicines


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Received on Tue Dec 20 2016 - 07:31:27 EST

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