NONMEM Users Network Archive

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Time varying volume of distribution implementation

From: Thorsten Lehr <thorsten.lehr>
Date: Fri, 22 Apr 2016 23:34:03 +0200

Dear NMusers,

I'm modeling a compound where body weight has a known impact on the
volume of distribution. This compound is investigated in pregnant women
over a long period (from gestational age of 8 weeks until they give
birth). Consequently, the body weight changes over time and I have a
decent formula to describe the individual body weight change. The PK
model has to be coded by ODEs. Does anyone has experience how to
integrate a time varying volume of distribution if differential
equations are used?

Best regards



Thorsten Lehr, PhD
Junior Professor of Clinical Pharmacy
Saarland University
Campus C2 2
66123 Saarbr├╝cken

Office: +49/681/302-70255
Mobile: +49/151/22739489

Received on Fri Apr 22 2016 - 17:34:03 EDT

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