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Some help with simulation with uncertainty using $PRIOR TNPRI

From: R.terHeine
Date: Mon, 11 Apr 2016 13:38:05 +0000

Dear all,

I would like to perform a simulation (based on a finished model), incorporating parameter uncertainty (for all theta’s, eta’s and epsilons) with the $PRIOR TNPRI option in Nonmem V7.3, using the results of the covariance step as an input. I am still struggling how to implement this. Does anybody have an example control stream I could look at?


Rob ter Heine

Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.
The Radboud university medical center is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.
Received on Mon Apr 11 2016 - 09:38:05 EDT

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