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RE: [NMusers] ASCO and pharmacometrics

From: Pascal Girard <pascal.girard_at_merckgroup.com>
Date: Wed, 6 Apr 2016 08:39:10 +0000

Dear Naoto,

In the past, Rene Bruno got one poster accepted with discussion at ASCO. He is our ”champion” !

I got one accepted on model for Exp-Tumor Size – OS at European Cancer Congress 2013 . But I can tell you that a medical writer rewrote it entirely and it took 1 month to get it reviewed and corrected by clinicians challenging every comma and p-value.

To give you an idea of the respective size of the meetings: ACOP N=500, PAGE N>600, ECC N> 10,000, ASCO N>20,000.

So the advice I would give, is just improve the quality and readability of our abstract and it will meke it. By readability, I mean show it to an oncologist clinician. If he does not understand, rewrite it with the help of a medical writer …

With best regards / Mit freundlichen Grüßen / Cordialement

Pascal

Vacation
7 April


From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Naoto Hayashi
Sent: 06 April 2016 09:46
To: jgrevel_at_btconnect.com
Cc: nmusers <nmusers_at_globomaxnm.com>
Subject: Re: [NMusers] ASCO and pharmacometrics

Dear Joachim,

Thank you so much for your reply.

Their abstract instruction allows very small number of characters, and no enough room to express what we had established in this work.

Although we described the unique results in the table, they probably could not understand its meaning, or the model's outcome that I was so excited has no meaning to oncologist.

It seemed so nice work for me and I hope that US pharmacometrician society would communicate with ASCO people for our future.

Thanks!

Best regards,
Naoto Hayashi, PhD


2016-04-06 15:58 GMT+09:00 Joachim Grevel <jgrevel_at_btconnect.com<mailto:jgrevel_at_btconnect.com>>:
Dear Naoto,
Your experience is also mine. For a combined TTE safety and efficacy analysis I earned the online publication. The organisers do not believe in modelling, unless it describes what is already visible in graphs and tables of raw data.
This is just my personal impression. I have not been to ASCO either.

Good luck,
Joachim


Joachim Grevel, PhD
Scientific Director
BAST Inc Limited
Science & Enterprise Park
Loughborough University
Loughborough, LE11 3AQ
United Kingdom

Tel: +44 (0)1509 222908<tel:%2B44%20%280%291509%20222908>
www.bastinc.eu<http://www.bastinc.eu/>



From: owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com> [mailto:owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com>] On Behalf Of Naoto Hayashi
Sent: 06 April 2016 02:38
To: nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>
Subject: [NMusers] ASCO and pharmacometrics


Dear all,

I have a question and appreciate it if somebody can answer to me.

We had submitted an abstract to ASCO annual meeting presentation 2016, and its contents included a pharmacometrics work of quantitative safety profile analysis of an anticancer drug. The behave of the safety index time courses is very unique and its results showed a very high usefulness of this drug. The abstract also included the table of population PK/PD parameters that expressed its nature, and it was compared with the similar older drug safety profile and demonstrated very high safer profile quantitatively.

I have some experiences to publish some articles of population PK/PD work in several clinical pharmacology journals in the past, and I was so confident for just a poster presentation in ASCO. However, the judgment was “publication only”, i.e. just presentation in online but no poster presentation and no official record of publication officially.

So, my question is whether pharmacometrics work is difficult to be picked up in ASCO presentation. Or, was my work evaluated to have no worth to be presented even in poster session because the pharmacometrics works presented in ASCO are having very high level?

I have never visited ASCO before, and I just want to hear opinions about how much of importance is considered for pharmacometrics work in ASCO.

Thanks a lot in advance for your comments/thoughts.

Best regards,
Naoto Hayashi




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Received on Wed Apr 06 2016 - 04:39:10 EDT

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