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Advanced course on Pharmacometrics

From: roberto gomeni <roberto.gomeni>
Date: Mon, 21 Sep 2015 10:55:04 +0200

Dear NMusers,


Register NOW…………

Advanced course on Pharmacometrics

16 - 18 Nov. 2015, Château de Longcol, Longcol, La Fouillade (France)


This is a 4-day course designed to develop and implement a
drug-disease-trial model strategy for optimizing the drug development
process using convolution-based methodologies and optimal design =


Course outline

* Determine the modelling strategy for characterizing the =
absorption processes for extended release formulations using
convolution-based approach

* Evaluate In-Vitro/In-Vivo correlation methods, including
convolution-deconvolution approach using the NONMEM software

* Evaluate the relationship between extended release drug =
and clinical response in presence of placebo effect and acute tolerance

* Determine the relationship between drug delivery and clinical

* Determine the In-Vitro drug release appropriate for optimizing =
clinical response

* <> Determine the optimal study
design methodology for study in a pediatric population for extended =
formulations using the PopED software


Course objectives

* To develop population PK models for describing multiphase
absorption profiles

* To evaluate alternative placebo response models

* To develop indirect-response model to jointly evaluate the =
and drug relate response

* To evaluate the relative impact of the immediate and the =
drug release on the therapeutic response

* To use convolution-deconvolution methods for linking in-vitro =
in-vivo outcomes

* To determine the optimal drug formulation profiles for =
the performances of novel drug formulations

* To evaluate optimal study design methodologies

* To present and use in the hands-on session an R based package =

a. the convolution/deconvolution analysis,

b. a clinical trial simulator for describing the clinical response in
presence of placebo and active drug response,

c. the estimation of the optimal in-vitro dissolution profiles


Additional details are available at:


Roberto Gomeni, PhD, HDR, Adjunct Professor at UNC


Longcol, 12270 La Fouillade (France)

E-mail: <mailto:roberto.gomeni


Next workshops on pharmacometrics:




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Received on Mon Sep 21 2015 - 04:55:04 EDT

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