NONMEM Users Network Archive

Hosted by Cognigen

Solver tool for excel and weighting strategy

From: Bharadwaj, Manushree <manushb>
Date: Sun, 20 Sep 2015 19:07:37 -0500


I have two questions:

A) I am going through the metrum institute videos about population PK PD
analysis. In Lab 2 (,
the instructor uses a tool called solver to perform iterations to determine
the least objective function value. The instructor is using a Mac (open
office). How can I get that tool or add-in in excel?

B) In the weighted least square example discussed in the video, the
weighting used is (1/observed concentration). What are the other common
weighting strategies? Is there any specific reason to prefer one weighting
strategy over the other?

Thank you,

*With regards-*
*Manushree Bharadwaj, BVSc, PhD Candidate*
*Graduate Teaching Assistant*
*Department of Physiological Sciences*
*Center for Veterinary Health Sciences*
*Oklahoma State University*
*Stillwater, OK-74074*

Received on Sun Sep 20 2015 - 20:07:37 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: