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Simcyp (a Certara company) Head of Modelling and Simulation (M&S) position

From: Masoud Jamei <masoud.jamei>
Date: Sun, 13 Sep 2015 21:33:47 +0100

*Closing Date for Applications: *Midnight (UK time), Sunday 11th October

*Line of Management: *VP of R&D

*Position Type: *Full Time

*Holiday Entitlement: *25 days, plus statutory bank holidays

*Salary: *£75,000 - £90,000 per annum dependent on qualifications=
experience (plus discretionary bonus, contributory pension scheme, private
health care *etc.*)

*Location:* Sheffield, UK

*Job Overview:*

We have an immediate opening for a highly motivated scientist with a
modelling and simulation background who wishes to combine scientific
excellences, innovations and advanced technologies to develop high impact
tools in the field of biosimulation for the benefit of patients. The
appointed individual will lead an established multi-disciplinary team of
scientists (10+) within the larger R&D group, who are active in various
aspects of *in-vitro* *in-vivo* extrapolation and mechanistic
physiologically based pharmacokinetics / pharmacodynamics (PBPK/PD)
modelling covering both small and larger molecules by applying top-down as
well as bottom-up modelling techniques. The role requires scientific
leadership and the supervision and management of various projects on
advanced modelling and simulation of absorption, distribution, metabolism,
transport and excretion processes in human and animal species. Prior
experience of predicting efficacy and safety of drugs and drug candidates
in virtual patient populations is an advantage.

The candidate is expected to mentor and scientifically support the M&S
team, keep abreast of the latest scientific developments and actively
engage with key opinion leaders within industry, academia and regulatory
agencies. A track record of communicating modelling activities and
delivering lectures in international professional meetings is a
requirement. The successful candidate will foster close collaboration and
coordination with other science teams including the translational science
and systems pharmacology groups and other colleagues within Certara and
promote cross-function interactions.

As the head of M&S s/he is also expected to actively plan and execute
internal and external educational activities including leveraging
international model-informed drug development workshops and client site
visits. The role also involves active interaction with the software
development team, devising software testing strategies, and providing
inputs into the software architecture and design of the Simcyp Simulators.


*Essential *

   - PhD in pharmaceutical sciences, pharmacology, computational biology,
   control or chemical engineering or related fields with more than 7 years=
   hands-on experience in model-based drug development;
   - Proven record of developing, managing and delivering projects
   involving complex multi-dimensional dynamic models;
   - Established track record of publications in high impact factor
   journals and being recognised among peers in the pharmaceutical modellin=
   - In depth knowledge of common tools for systems pharmacology such as
   Simcyp, Phoenix, R, MATLAB, etc.;
   - Excellent record of communication skills, as evident by presentation
   at various scientific meetings, and exceptional interpersonal and
   organizational skills;
   - Proven record of successful managing of a multidisciplinary group of


   - In depth awareness of pharmaceutical R&D;
   - Well-informed about the FDA, European and Japanese regulatory guidance
   on application of M&S;
   - Working knowledge of PopPK/PD modelling, clinical trial simulation and
   optimal design, disease progression modelling, model based meta-analyses=
   - Familiarity with various in vitro ADME methodologies.

*Company Overview:*

Simcyp is part of Certara, a company which combines sophisticated research
and development informatics with the power of predictive science
methodologies to span the drug development spectrum and offer pharma a
previously unavailable ‘end-to-end’ solution in the quest f=
or improving
human health. The Simcyp team conducts cutting-edge research and provides
consultancy, knowledge integration tools, algorithms, modelling solutions
and databases (implemented in its globally-recognised Simcyp
Population-based Simulator) for a client base of major blue-chip
pharmaceutical and biotechnology organisations. Simcyp focuses, in
particular, on gathering information required for the modelling and
simulation (M&S) of the individual time-course and fate of drugs. We are on
course to become the global industry standard, consequently, there is a
continuous requirement for high quality people to join us, help in our
expansion and share in our success.

*Applications: *

Please send your CV, covering letter and the names of two references
quoting M&S/Sept/Sim to:

   - *Email:* *recruitment
   - *Post:* Recruitment, Simcyp, Blades Enterprise Centre, John Street,
   Sheffield, S2 4SU, UK


Received on Sun Sep 13 2015 - 16:33:47 EDT

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