NONMEM Users Network Archive

Hosted by Cognigen

[NMusers] Estimation of ke0 from raw data

From: Lommerse, JPM (Jos) <"Lommerse,>
Date: Sat, 5 Sep 2015 19:43:45 +0200

Hi,

I have a data set containing PK concentrations and PD effect.
When plotting PD as a function of PD a clear anti-clockwise hysteresis
plot appears.
I would like to get a (rough) estimate of the PD time delay w.r.t. the PK without
using a compartmental description for the observed PK, even not using
a polynomal function that fits the PK. The assumption I make is that
all PD delay can be explained by the delay through an effect compartment.
I am wondering if methods exist that solely use the raw data to
calculate such time delays.

Thank you for any comment/suggestion,

Jos

Jos Lommerse
Modeler Consultant
Quantitative Solutions BV
Molenweg 79
5349 AC Oss
The Netherlands
jlommerse_at_wequantify.com<mailto:jlommerse_at_wequantify.com>
+31 412 211102


Notice: This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from
your system.


Received on Sat Sep 05 2015 - 13:43:45 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request_at_iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.