NONMEM Users Network Archive

Hosted by Cognigen

Re: Estimation of ke0 from raw data

From: Mukul <mukul.minocha>
Date: Sat, 5 Sep 2015 14:27:26 -0400

Hi Jos,

Why not try the indirect response model instead? The fixed effects are more i=
nterpretable pharmacologically than just using Ke0.
The initial estimate of the first order rate constant of degradation (kout) o=
f response could be the slope of the decline of the response when plotted wi=
th time.

You can read more in detail as there is lot of literature if you are not fam=
iliar with these models.


Mukul Minocha

> On 05-Sep-2015, at 13:43, Lommerse, JPM (Jos) <jos.lommerse
> Hi,
> I have a data set containing PK concentrations and PD effect.
> When plotting PD as a function of PD a clear anti-clockwise hysteresis
> plot appears.
> I would like to get a (rough) estimate of the PD time delay w.r.t. the PK w=
> using a compartmental description for the observed PK, even not using
> a polynomal function that fits the PK. The assumption I make is that
> all PD delay can be explained by the delay through an effect compartment.
> I am wondering if methods exist that solely use the raw data to
> calculate such time delays.
> Thank you for any comment/suggestion,
> Jos
> Jos Lommerse
> Modeler Consultant
> Quantitative Solutions BV
> Molenweg 79
> 5349 AC Oss
> The Netherlands
> jlommerse
> +31 412 211102
> Notice: This e-mail message, together with any attachments, contains
> information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth, =

> New Jersey, USA 07033), and/or its affiliates Direct contact information
> for affiliates is available at
> that may be confidential,
> proprietary copyrighted and/or legally privileged. It is intended solely
> for the use of the individual or entity named on this message. If you are
> not the intended recipient, and have received this message in error,
> please notify us immediately by reply e-mail and then delete it from
> your system.

Received on Sat Sep 05 2015 - 14:27:26 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: