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Estimation of ke0 from raw data

From: Lommerse, JPM <jos.lommerse>
Date: Sat, 5 Sep 2015 19:43:45 +0200


I have a data set containing PK concentrations and PD effect.
When plotting PD as a function of PD a clear anti-clockwise hysteresis
plot appears.
I would like to get a (rough) estimate of the PD time delay w.r.t. the PK without
using a compartmental description for the observed PK, even not using
a polynomal function that fits the PK. The assumption I make is that
all PD delay can be explained by the delay through an effect compartment.
I am wondering if methods exist that solely use the raw data to
calculate such time delays.

Thank you for any comment/suggestion,


Jos Lommerse
Modeler Consultant
Quantitative Solutions BV
Molenweg 79
5349 AC Oss
The Netherlands
+31 412 211102

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Received on Sat Sep 05 2015 - 13:43:45 EDT

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