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Re: [NMusers] NM-Tran infer data are single subject when perform simulation

From: Leonid Gibiansky <lgibiansky_at_quantpharm.com>
Date: Thu, 29 Oct 2015 15:57:22 -0400

you need to add dummy sigma record
$SIGMA
   0 FIXED ; [A] Dummy
Leonid


--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 10/29/2015 3:03 PM, Tommy Li wrote:
> Hello
>
> I have population data set that I fitted to a model. However, when I try
> to use the exact data set and model to perform simulation, I encounter
> the situation where NM-Tran infer the data as single subject. Is there a
> reason why this happens? Also, how do I force NM-Tran to infer data as
> population for simulation in this case?
>
> To perform simulation I just change from $EST to $SIM. I have done this
> before with other model and data set before with no problem. I did the
> same with current model.
>
> Here is the beginning and end of my model code:
> $INPUT ID PART TRT PTIM PTM2 TM TSLD AMT D FLAG CMT FBQL EVID MDV AGE
> SEX WGT HGT BSA DIAB HTN HLIP ETOH SMOK BDAS BSJC BTJC BCRP WBC ALB ALT
> AST CRCL ACR20 ACR50 ACR70 TIME TIME_ DV DV_ ACR50C ACR50P ACR70C ACR70P
> KAI CLI VI
>
> $DATA pddataACRTIMECOR.csv IGNORE=_at_
>
> $SUBROUTINES ADVAN6 TOL=10
> $SUBROUTINES OTHER=bivariate.f90
>
> $MODEL NCOMP=3 COMP=DEPOT COMP=CENTRAL COMP=EFFECT
> $PK
> .....
> $ERROR
> .....
> $THETA
> .....
> $OMEGA
> .....
> $EST MAX=8000 PRINT=2 METHOD=1 LAPLACE -2LL SIGL=10 NOHABORT
> $COV COMPRESS MATRIX=R PRINT=E UNCONDITIONAL
>
> For simulation, I just change the $EST block to $SIM
> $SIM (547676) (523842) ONLYSIM SUBPROBLEMS=1
>
> Thank you
> Tommy Li
Received on Thu Oct 29 2015 - 15:57:22 EDT

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