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Pediatric brain scaling

From: Mark Sale <msale>
Date: Mon, 16 Nov 2015 16:56:26 +0000

Dear Colleagues,

  I'm working on a drug that is administered intrathecally to kids and adul=
ts. I'm interested in scaling pk from adults to kids (whose brains start ou=
t relatively large, compared to the body, but reach maximum size in the tee=
ns, then stop growing). I'm a little surprised that I can't find anything =
about dosing CNS drugs to peds, based on brain weight (and, ideally, brain =
clearance). Does anyone know of anything?



Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. (tm)
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383

Empower your Pipeline

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Received on Mon Nov 16 2015 - 11:56:26 EST

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