NONMEM Users Network Archive

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Re: eigenvalues

From: Ken Kowalski <ken.kowalski>
Date: Fri, 6 Nov 2015 11:04:29 -0500

Dear Pavel,

Are you using MATRIX=R when using NONMEM or the default sandwich estimator=
 for the covariance matrix? Most nonlinear regression packages use the equi=
valent of MATRIX=R in NONMEM. You might try MATRIX=R on the $COV step a=
nd then compare to Monolix.

Ken

Sent from my iPhone

> On Nov 6, 2015, at 8:42 AM, Pavel Belo <nonmem
>
> unstable in the middle with or without simulated annealing.
>
> I do not take sides. I just try to understand it. As max/min is frequent=
ly reported in BLAs, it is nice to understand what we report
Received on Fri Nov 06 2015 - 11:04:29 EST

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