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Re: [NMusers] scm problem

From: Muhammad Usman <usman.ips_at_gmail.com>
Date: Thu, 28 May 2015 10:59:50 +0200

Dear Ron,
Thank you very much for your guidence. I have gone through this
tutorial and now I understand the process for scm.

Regards

On 28 May 2015 at 01:06, Ron Keizer <ronkeizer_at_gmail.com> wrote:

> hi Muhammad,
>
> a brief guidance on how to do a stepwise covariate search with PsN+Pirana
> is given in our recent tutorial in CPT-PSP (
> http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.24/abstract), in
> which we used the scm tool in PsN, and Pirana to generate the scm config
> file. Let me know if you don't get the example to run. (Someone reported
> recently that the appendix files were not available anymore, but they are
> also here: https://github.com/ronkeizer/ppx_tutorial)
>
> Of course—if you keep having trouble getting the scm tool to run=
—you
> could choose to implement and run the covariate models manually: for only
> five covariates there is only little gain in using the scm tool. A gentle
> introduction on how to build covariate models in NONMEM is available in
> chapter 5.7 of the recent book by Owen and Fiedler-Kelly (
> http://www.amazon.com/Introduction-Population-Pharmacokinetic-Pharmacodyn=
amic-Nonlinear/dp/0470582294/
> ).
>
> best regards,
> Ron
>
> PS. any Pirana-specific questions can also be posted at
> http://qa.piranasoftware.com
>
>
> On Wed, May 27, 2015 at 6:35 AM, Muhammad Usman <usman.ips_at_gmail.com>
> wrote:
>
>> Dear NMUsers
>> I am a beginner with NONMEM. I have developed a model and want to use
>> AGE, WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone
>> provide me the step by step guidence how can I perform this Analysis by
>> using Pirana?
>>
>> Regards
>>
>> --
>> *Muhammad Usman*
>> PhD Scholar
>> Westfälische Wilhelms-Universität Münster
>> Institut für Pharmazeutische und Medizinische Chemie
>> - Klinische Pharmazie -
>> Corrensstrasse 48
>> 48149 Münster
>>
>> Room No. A120.209
>>
>> Phone: +49 251/8332171
>>
>> Mob # +49 176 70962067
>>
>
>


--
*Muhammad Usman*
PhD Scholar
Westfälische Wilhelms-Universität Münster
Institut für Pharmazeutische und Medizinische Chemie
- Klinische Pharmazie -
Corrensstrasse 48
48149 Münster

Room No. A120.209

Phone: +49 251/8332171

Mob # +49 176 70962067

Received on Thu May 28 2015 - 04:59:50 EDT

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