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Postdoc Mathematical Pharmacology

From: Graaf, P.H. van der <p.vandergraaf>
Date: Wed, 27 May 2015 08:23:11 +0000

Postdoc Mathematical Pharmacology

The Leiden Academic Centre for Drug Research (LACDR) and AstraZeneca (AZ), =
vacancy 15-169

The Leiden Academic Centre for Drug Research (LACDR) and AstraZeneca (AZ) a=
re looking for a:
Postdoc Mathematical Pharmacology (0.8 - 1.0 fte)
Vacancy number: 15 -169

Project description

LACDR and AZ have recently established a collaboration to develop novel mec=
hanistic PKPD models to describe, understand and predict regulatory feedbac=
k mechanisms. Such models should have broad application in translational dr=
ug discovery and development across therapeutics areas and should provide a=
 novel framework to optimize dosing schedules based on mechanistic understa=
nding of regulatory feedback mechanisms such as tolerance and rebound. We a=
re therefore looking to appoint a postdoc Mathematical Pharmacology.
The emphasis of the position is on research, but it is our philosophy that =
our students get taught by our best researchers. It is therefore expected t=
hat every member of staff spend *20% of their time on teaching duties.

Selection criteria

The ideal candidate for this unique position will have a PhD in Mathematics=
, Engineering, Physics or a related discipline and will combine excellent q=
uantitative skills with a strong desire to apply computational approaches i=
n drug discovery and development and biomedical research.

About our organization

The Leiden Academic Centre for Drug Research (LACDR) is a leading institute=
 dedicated to world-class research and education in drug discovery and deve=
lopment. LACDR comprises a diverse and international team of approximately1=
50 researchers and is ideally located at the Leiden Bio Science Park, the l=
argest life science cluster in The Netherlands. In the 2015 QS World Univer=
sity Ranking, the University of Leiden was listed number 9 globally in the =
area of Pharmacy and Pharmacology. LACDR has a world-leading reputation in =
the field of mechanism-based pharmacokinetic-pharmacodynamic (PKPD) modelli=
ng and a growing focus on using computational approaches in the areas of dr=
ug research, such as pharmacometabolomics, medicinal chemistry and toxicolo=
AstraZeneca (AZ) is a leading multi-national R&D based biopharmaceutical co=
mpany and employs 9,000 R&D people world-wide developing medicines for diab=
etes, obesity, arthritis, central nervous system and pain, oncology and inf=
ection. The Drug Metabolism and Pharmacokinetics (DMPK) department supports=
 aspects of drug distribution and metabolism and human dose predictions for=
 drug R&D projects, including those in clinical development. Within DMPK si=
t Modelling and Simulation (M&S) groups associated with each therapy area, =
supporting the discovery and development of therapeutic agents. These group=
s collaborate via the Centre of Excellence (CoE) on training, software, mod=
elling methods and scientific collaborations. Research within AZ is partly =
funded internally, including PhD studentships and Postdoc Fellowships (curr=
ently numbering 75 with an aim to double this in the next two years) who sp=
end time at AZ and at partner universities.

Terms and conditions

We offer a position for an initial period of one year with an extension of =
up to two additional years subject to performance. Pay scale 10 or 11, in a=
ccordance with the Collective Labour Agreement for Dutch Universities. We a=
im to employ more women in areas where they are underrepresented. Women are=
 therefore especially invited to apply.
An appointment at Leiden University includes a pension build-up and other b=
enefits; these include an annual holiday premium of 8%, an end-of-year prem=
ium of 8.3% and a paid parental leave of 62,5%. It is possible to accumulat=
e extra hours leave. We take a positive view on flexible working to accommo=
date work-life balance. The position is fulltime but an appointment for 0,8=
 FTE is also possible. There are excellent options for child day care in th=
e near working area. Leiden University strongly believes that innovation re=
quires a diverse organization and workforce. Women are strongly encouraged =
to apply.
Candidates from outside the Netherlands may be eligible for a substantial t=
ax break. The candidate will be collaborating closely with scientists at As=
traZeneca and will be given the opportunity to travel to AZ research sites =
for working visits. Located only 30 minutes from Amsterdam Schiphol Airport=
, Leiden is ideally situated for international travel.


For further enquiries please contact Piet van der Graaf (wd<mailto:wd<mailto:james.yates
If you have any questions about the procedure, please contact Mrs. A. Poels=
 (e-mail: farmacol
, telephone: +31 71 527 6211).Information about the faculty of science can =
be found at and about L=
eiden University at


To apply for this vacancy, please send an email to Piet van der Graaf (wd Please ensure that you quote the vacancy number in the=
 subject header and upload the following additional documents quoting the v=
acancy number:
* Application letter
* CV
* List of publications
Only applications received before July 1st 2015 can be considered.

Received on Wed May 27 2015 - 04:23:11 EDT

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