NONMEM Users Network Archive

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[NMusers] RE: tracer-tracee kinetics

From: Bonate, Peter <Peter.Bonate_at_astellas.com>
Date: Wed, 6 May 2015 14:33:35 +0000

Ann

There is a great book on this by David Foster. It is sold on Amazon but is=
 kind of expensive.

http://www.amazon.com/Tracer-Kinetics-Biomedical-Research-Model/dp/03064642=
76

I think this could be an invaluable resource for you.

pete

Peter L. Bonate, PhD
Executive Director
Global Head - Pharmacokinetics, Modeling, and Simulation
Global Clinical Pharmacology & Exploratory Development

Astellas
1 Astellas Way, 2N.184
Northbrook, Il 60062
phone: 224-205-5855
fax: 224-205-5914
email: peter.bonate_at_astellas.com


From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Ann Rigby-Jones
Sent: Wednesday, May 06, 2015 5:23 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] tracer-tracee kinetics

Dear NONMEM Users Group

I have been asked to help with modelling saliva concentration data from a t=
racer-tracee study of an endogenous substance. Human volunteers were given =
an oral dose of the labelled tracer substance and a series of saliva sample=
s were collected over the following 24 hours.


* The dependent variable is in the form of a ratio (unitless) of th=
e tracer to tracee (endogenous) saliva concentrations.


* The dose amount (micromoles) and time of dose are known. The dos=
e is given as the oxidised form of the measured compound.


Modelling it as a 2-compartment mammillary model with a depot compartment p=
roduces reasonable plots but of course, the output data is not useful.

My questions are:

1) How does one work with a ratio as a DV and make sense of the output data=
?

2) Would a metabolite model be a suitable way of dealing with the dose bein=
g in a different chemical form to that measured? Is there a better way?

3) Can anyone guide me towards similar published work?


Grateful for any advice. With thanks and all best wishes

Ann

Dr Ann Rigby-Jones
Lecturer in Pharmacology, Anaesthesia Research Group
Plymouth University Peninsula Schools of Medicine & Dentistry

Website: www.plymouth.ac.uk/peninsula<http://www.plymouth.ac.uk/peninsula>
[Facebook] /pupsmd<http://www.facebook.com/pupsmd> [Twitter] /pupsmd<http=
://www.twitter.com/pupsmd>

[PUPSMD logo]


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Received on Wed May 06 2015 - 10:33:35 EDT

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