NONMEM Users Network Archive

Hosted by Cognigen

Novartis-Senior Principal Pharmacometric Scientist (USA)

From: Graham, Gordon <gordon.graham>
Date: Tue, 12 May 2015 19:12:08 +0000

Novartis - Senior Principal Pharmacometric Scientist Position

Novartis is committed to discover, develop and successfully market innovati=
ve products to prevent and cure diseases, to ease suffering, and to enhance=
 the quality of life. The Pharmaceuticals division is at the forefront of d=
evelopment and commercialization in oncology, primary care and specialty me=
dicines. The pharmacometric modeling group at Novartis is a key partner in =
supporting clinical development by applying modeling and simulation to info=
rm drug development. This group supports all clinical development programs =
in general medicines through the application of model based approaches to c=
haracterize dose-exposure-response relationships, disease progression, drug=
 delivery, as well as understand the translational feasibility of new modal=
ities of treatments in humans.

The group is focused on delivering strategic and well-timed modeling input =
at key decision points along the development path. Members of the group are=
 expected to be technically capable modelers and are encouraged to develop =
strategically as scientific partners and stakeholders that help inform drug=
 development process for novel small molecules, biologics and cell & gene t=

The Senior Principal Pharmacometric Scientist role has responsibility in pl=
anning, execution and delivery of modeling and simulation strategy on assig=
ned projects within (pre/early/full) clinical development. S/he is responsi=
ble for the discussion and implementation of pharmacometric methodologies t=
hat optimally address the research and development objectives on the assign=
ed projects. S/he provides pharmacometric support for regulatory submission=
s, and contributes to drug development decisions with internal and external=
 partners. In this role, the associate is expected to identify the relevant=
 development questions that would benefit from model-based methods and deve=
lop modeling plans to deliver meaningful and timely results clearly to dev=
elopment teams.

The scope of modeling activities include population PK/PD models, drug-dise=
ase models, clinical trial simulations, literature meta-analyses, and othe=
r state of the art modeling and simulation techniques. Key technical respon=
sibilities are to organize, execute, and report modeling and simulation ind=
ependently, as well as to present work at cross-functional teams, departmen=
tal meetings, senior management review committees, regulatory interactions,=
 and scientific conferences.

Candidates should have requisite expertise in quantitative pharmacology, st=
rong hands-on modeling and simulation skills, and demonstrated impact on dr=
ug development through quantitative approaches. Rich hands-on experience wi=
th NONMEM, Monolix, SPLUS, R, Matlab and/or other modeling and simulation s=
oftware is required. Experience with mechanistic PK/PD and/or system pharma=
cology modeling is desired. The candidate must have excellent communication=
 and interpersonal skills and the ability to work independently and effecti=
vely on interdepartmental project teams.

A Ph.D. in pharmacology, biology, engineering, mathematics, statistics, or =
a field with significant modeling-related content (or equivalent Ph.D. / MD=
) Fluent in English (Oral and written) required
5+ years industry experience required.
2+ years in applying model based methods in pre-clinical and clinical drug =
Good interpersonal and communication skills (verbal and writing) bridging s=
cientific and business needs - integrating quantitative sciences, strong di=
sease area knowledge and appropriate market/competitive intelligence.
Expert knowledge and evidence of hands-on experience in the application of =
pharmacometrics methods to drug development.
Scientific skills demonstrated in facilitating the (pre/early/full-) clinic=
al development strategy.
Clinical, pharmacological and therapeutic knowledge of at least one disease=
 area preferred.

Please apply through these links

Ramprasad "Prasad" Ramakrishna
Novartis Institutes for BioMedical Research, Inc., 45 Sidney Street, Cambri=
dge, MA 02139, USA

Received on Tue May 12 2015 - 15:12:08 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: