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Senior Pharmacometrician (Director/Associate Director) opportunity at Vertex, Boston

From: Ulf Bredberg <Ulf_Bredberg>
Date: Tue, 23 Jun 2015 20:38:05 +0000

Senior Pharmacometrician- Associate Director/Director at Vertex, Boston

Modeling & Simulation methodologies plays an increasingly important role in=
 the development of new drugs within Vertex Pharmaceuticals and our goal is=
 to fully implement Model based principles to support drug development prog=
ram in terms of translational modeling, clinical trial design, dose selecti=
on and to improve critical decision making.
We are now seeking an experienced Pharmacometrician to our Modeling & Simul=
ations (M&S) group to help us achieve this vision.
The successful candidate will be responsible for developing and executing M=
&S strategies in cross functional drug development project teams in close c=
ollaboration with colleagues in Clinical Pharmacology, Biostatistics, Resea=
rch and other colleagues within the clinical and preclinical organization. =
The successful candidate will play a key role in building the Pharmacometri=
cs and Modeling capability within Vertex by strongly contributing to the co=
ntinuous improvement of our technical skill, computational infrastructure a=
nd the strategic use of M&S methodologies across our projects and disease a=

Key responsibilities

* As M&S lead in one or more cross functional drug development team=
s, develop and execute Modeling & Simulation plans fully integrated with th=
e overall clinical plans

* By using state of the art Modeling&Simulation methodologies stron=
gly contribute to decision making at critical milestones based on quantitat=
ive principles in close collaboration with Biostats, Clin Pharm and other q=
uantitative disciplines

* Perform population PK, PKPD-analyses, Clinical trial simulations=
 and other model based analyses on a regular basis

* Initiate and coordinate outsourced Modeling&Simulation activities=
 when appropriate

* Provide technical and tactical support to other Modeling colleagu=

* Strengthen our internal Modeling&Simulation capability on a con=
tinuous basis by initiating training activities, evaluating and incorporat=
ing new M&S tools as appropriate

Required Qualifications

* PhD in PKPD, Clinical pharmacology, or other quantitative discip=
line with an emphasis Pharmacometric methodologies

* 10 yrs hands-on experience in the application of Pharmacometrics =
within the context of drug development.

* Expert hands-on skills from population-based PKPD modeling, Clini=
cal trial simulation and optimal design, probability of success calculation=
s, Disease progression modeling, Meta analyses etc.

* A solid understanding of fundamental pharmacokinetic and quantita=
tive pharmacology (PKPD) principles.

* Excellent programming skills (NonMem, R, Phoenix, SAS and other s=
imilar tools)

* Demonstrated strong leadership- and influencing skills

* Excellent collaborative, verbal and written communication skills

* Experience from Regulatory interactions and guidelines relevant f=
or M&S

Desirable qualifications

* Experience from Pharmacometric approaches in Pulmonary diseases, =
Oncology and Neurological disorders.

* Experience from the application of System pharmacology methodolog=
ies in a drug development context

If you are interested in the above position, please send your resume to: S=
tephen Krenitsky, Director Talent Acquisition, Vertex Pharmaceuticals, Bost=
on, MA, USA. Email: Stephen_krenitsky> Vertex is an Equal Opportunity Employer.

Ulf Bredberg, Ph.D.
Sr Director, Head of Modeling&Simulations
Vertex Pharmaceuticals
50 Northern Avenue
Boston, MA 02210
Office: 1-617-961-0622
Mobile: 1-857-523-1077
Email: ulf_bredberg

This email message and any attachments are confidential and intended for us=
e by the addressee(s) only. If you are not the intended recipient, please n=
otify me immediately by replying to this message, and destroy all copies of=
 this message and any attachments. Thank you.

Received on Tue Jun 23 2015 - 16:38:05 EDT

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