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RE: [NMusers] Implementation of the OMEGA covariance matrix

From: Rudy Gunawan <RGunawan_at_isisph.com>
Date: Tue, 28 Jul 2015 13:22:14 +0000

Hi Ana,

What you can do is rearrange your ETA order, ie, the full block and the res=
t as with a separate '$OMEGA'
$OMEGA BLOCK(3)
0.09 ; V1
0.01 0.09 ;BMAX
0.01 0.01 0.09 ;KM
$OMEGA ...

Hope this helps,

Rudy

-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Ana Miranda Bastos
Sent: Tuesday, July 28, 2015 5:52 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Implementation of the OMEGA covariance matrix

Dear NMusers,

I wonder if someone could help me to implement the OMEGA covariance matrix =
below.

$OMEGA
 0.09 ; PPV_VMAX
 0.00 0.09 ; PPV_V1
 0.00 0.00 0.09 ; PPV_V2
 0.00 0.00 0.00 0.09 ; PPV_KD
 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX
 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM


I don't want to fix any value to zero, but I don't know how to better illus=
trate that I would like to consider a covariance between:
. V1 and Bmax
. Bmax and Km
. V1 and Km


Any advice is highly appreciated. Thank you in advance.

Kind regards,

Ana



------------------------------------------
Ana Bastos, Pharm, MSc, PhD student
Pharmacologie cellulaire et moléculaire
(Cellular and Molecular Pharmacology Unit)
Louvain Drug Research Institute
Université catholique de Louvain (Catholic University of Louvain)
UCL 7370 avenue E. Mounier 73
1200 Bruxelles, Belgique
------------------------------------------
http://www.facm.ucl.ac.be

Received on Tue Jul 28 2015 - 09:22:14 EDT

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