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Re: [NMusers] Is it reasonable to add covarite to PD parameters kin or kout?

From: Leonid Gibiansky <lgibiansky_at_quantpharm.com>
Date: Mon, 27 Jul 2015 15:37:13 -0400

one option is to use BASE and KOUT as primary parameters and compute
KIN=BASE*KOUT
Then one can either fix BASE=(observed base) or use
BASE=(observed base)*EXP(ETA())
to account for the random noise of observations.

Leonid


--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 7/27/2015 2:39 PM, Zhao,Li wrote:
> Dear NMusers,
>
>
> Right now I am doing covarite analysis for an indirect response model.
>
>
> I tested a few potential covarites and found it's STATISTICALLY
> significant if I add *observed baseline valu*e to *kin*.
>
>
> But I am not sure if it makes sense to add t/he baseline value/ as a
> covarite to /kin/.
>
>
> Could you please help me if you have had similar experiences before?
>
>
> Thank you very much!
>
Received on Mon Jul 27 2015 - 15:37:13 EDT

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