NONMEM Users Network Archive

Hosted by Cognigen

RE: Implementation of the OMEGA covariance matrix

From: Krekels, E.H.J. <e.krekels>
Date: Tue, 28 Jul 2015 13:24:20 +0000

Dear Ana,

If you only want to consider covariance between 3 parameters, I suggest you=
 put these three in an $OMEGA BLOCK(3) and list the remaining OMEGAs separa=
tely outside the block.


-----Original Message-----
From: owner-nmusers
 Behalf Of Ana Miranda Bastos
Sent: Tuesday, July 28, 2015 2:52 PM
To: nmusers
Subject: [NMusers] Implementation of the OMEGA covariance matrix

Dear NMusers,

I wonder if someone could help me to implement the OMEGA covariance matrix =

 0.09 ; PPV_VMAX
 0.00 0.09 ; PPV_V1
 0.00 0.00 0.09 ; PPV_V2
 0.00 0.00 0.00 0.09 ; PPV_KD
 0.00 0.01 0.00 0.00 0.09 ; PPV_BMAX
 0.00 0.01 0.00 0.00 0.01 0.09 ; PPV KM

I don't want to fix any value to zero, but I don't know how to better illus=
trate that I would like to consider a covariance between:
. V1 and Bmax
. Bmax and Km
. V1 and Km

Any advice is highly appreciated. Thank you in advance.

Kind regards,


Ana Bastos, Pharm, MSc, PhD student
Pharmacologie cellulaire et moléculaire
(Cellular and Molecular Pharmacology Unit)
Louvain Drug Research Institute
Université catholique de Louvain (Catholic University of Louvain)
UCL 7370 avenue E. Mounier 73
1200 Bruxelles, Belgique
Received on Tue Jul 28 2015 - 09:24:20 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: