NONMEM Users Network Archive

Hosted by Cognigen

RE: [NMusers] Time 'T' in $Error

From: Denney, William S. <William.S.Denney_at_pfizer.com>
Date: Mon, 27 Jul 2015 15:34:20 +0000

Hi Katrin,

$ERROR is executed once per data row. The time when $ERROR is run is the T=
IME value (the discrete times of the measurement). For this specific examp=
le, you can just use TIME. You will need to code your $DES block so that w=
hat you're wanting to integrate as a function of time is in a compartment a=
mount (e.g. A(1)). With your example, it's hard to see how T is used in th=
e $DES, but perhaps you could share the real example to give a bit more con=
crete advice on how to integrate the answer into your code.

Thanks,

Bill

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Katrin Volz
Sent: Monday, July 27, 2015 10:46 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Time 'T' in $Error

Dear NMuser,

I would like to model a PD effect using a function which includes continuou=
s time ' T '.

The PD Effect is coded in $Error.
In general like this:
$ERROR
MyFunction = xxx + T
PDEffect = Basline * MyFunction

But 'T' cannot be used in $Error.

I tried to code the function with 'T' in $DES and rename it to use it in $E=
RROR:

$DES
MyFunction = xxx + T
$ERROR
MyNewFunction = MyFunction
PDEffect = Baseline * MyNewFunction

but it didn't worked (to rename was not permitted by NONMEM).

Does anyone of you has an idea how to solve this problem?

Thanks and best regards.
Katrin



Anke-Katrin Volz
PhD Student
Saarland University
Clinical Pharmacy
Campus C2 2 | Room 0.31
D- 66123 Saarbrücken

mail ankekatrin.volz_at_uni-saarland.de<mailto:ankekatrin.volz_at_uni-saarland.de=
>
fon +49 [0]681 302 22 84
fax +49 [0]681 302 70 258
www.clinicalpharmacy.me<http://www.clinicalpharmacy.me>


Received on Mon Jul 27 2015 - 11:34:20 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request_at_iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.