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Merck Serono: Manager in Pharmacometrics position

From: pascal.girard
Date: Thu, 19 Feb 2015 14:40:39 +0000

At Merck Serono, we discover, develop, manufacture and market innovative sm=
all molecules and biopharmaceuticals in our focus therapeutic areas:
* Oncology
* Neurodegenerative diseases
* Fertility
* Endocrinology
* CardioMetabolic Care
With headquarter in Darmstadt, Germany, and over 16,000 people worldwide, w=
e're active on all continents and offer leading brands in 150 countries. In=
 the United States and Canada, EMD Serono operates through separately incor=
porated affiliates.

Merck Serono is seeking a creative, motivated scientists to join our Pharma=
cometric department as local Manager. The position will be based in Darmst=
adt (Germany).

To apply please visit the careers pages on https://career012.successfactor= and enter the Requisition ID: 41221.

The manager will report to the head of pharmacometry. He will have her/his =
own pharmacometric project and will also have to lead and provide input a=
nd guidance to a local team of senior pharmacometricians who develop M&S me=
thodologies and expertise in drug development and make them available to fa=
cilitate more efficient and informative clinical trials, inform decision ma=
king, and globally support Clinical Pharmacology, Exploratory Medicine, Cli=
nical Development, Clinical Teams and Projects.

* Being an established senior scientist
* 5 to 7+ years experience in PKPD Modeling, of which 3+ in Bio=
Pharmaceutical Industry.
* Having successfully run pharmacometric project in drug develo=
pment and/or having some experience of management over a small team of phar=
* Experience with PKPD M&S input into drug development.

* Globally support the Quantitative Pharmacology department wit=
hin Global Early Development
* Provide M&S input into Clinical Development Plans
* Participate to sound translational science, from animal to he=
althy subjects, to patients, to special populations
* Plan, perform, interpret, present, track and record M&S-relat=
ed activities within allocated projects and studies
* Keep up-to-date with scientific development in M&S, and regul=
atory guidance and trends
* Develop internal expertise in advanced population PKPD modeli=
ng, with emphasis on physiological and mechanistic approaches
* Explore, evaluate and implement appropriate pharmacometric to=
ols and methodologies; participate to the improvement of the M&S processes =
and technological platform
* Representation of the whole of Quantitative Pharmacology in t=
ransactions with internal and external stakeholders

* Master or higher degree in Clinical Sciences related discipli=
nes (Medicine, Physiology, Pharmaceutical Sciences, etc) and strong experti=
se in Pharmacometrics/biostatistics. Alternatively, degree in Mathematics/S=
tatistics and strong experience in clinical development.
* Fluent in written and oral English
* Fluency in other European languages, particularly German, is =
an asset

* Good command of NONMEM is an absolute prerequisite, experienc=
e with MONOLIX is an asset.
* Good command of R is an absolute prerequisite, experience wit=
h SAS is an asset.
* Experience with PsN and Xpose is another asset.
* Experience with Clinical Trial Simulation tools is another as=
set, alike for other analytical/modeling/ optimization/presentation softwar=
* Experience in writing and using PKPD models, particularly mec=
hanistic-models and in developing disease progression models is an asset.
* Overall good knowledge of common PC software.

* Strong problem solving skills and ability to analyze complex =
* Has interest in, and knowledge of, both mathematical and (pat=
ho-)physiological aspects of M&S in drug development
* Is enthusiastic, self-motivated and has good communication sk=
ills, and at ease in working in a dynamic matrix organization; is a team-pl=
ayer. Communicate technical details effectively with scientists and clinici=
ans colleagues

To apply please visit the careers pages on https://career012.successfactor= and enter the following Requisition ID 4=
1221 for the manager position in Darmstadt.

With best regards,

Pascal Girard
Director, Head of Pharmacometry
Merck Serono | Global Early Development

        "Merck - Living Innovation"

Merck Institute for Pharmacometrics - Merck Serono S.A.
EPFL Innovation Park - Building I, CH-1015 Lausanne, Switzerland
Phone: +41 21 900 3702 | Mobile: +41 79 508 7898
Email: pascal.girard<>
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Received on Thu Feb 19 2015 - 09:40:39 EST

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