NONMEM Users Network Archive

Hosted by Cognigen

Sampling and sample size for pkpd analysis

From: Bernard Ngara <bernardngara4>
Date: Tue, 17 Feb 2015 18:38:52 +0200

Dear all

I would like to apply pkpd-vd analysis to quantify the impact of
HAART(based) prophylaxis to the rate of mother to child transimission
and progression of HIV-1 in mother and child pairs expected to be
followed up for a minimum of 2 years. Can you please assist me on the
following issues:

1. What are the methods to use for determining the minimum number of
mother and newborn pairs to be included for pkpd-vd analysis?

2. What are the minimum number of blood samples and optimal sampling
times should i collect from both mother and newborn pairs to obtain an
accurate measure of the drug and viral load levels over the 2-year

Primary covariates to be included in the analysis are CYP2B6, CYP3A4 and ABCB1.

Your comments and suggestions are welcome.


PhD Student, University of Zimbabwe

Bernard Ngara
Trainee Biostatistician
Africa Institute of Biomedical Science and Technology
P. O Box 2294
+263 772 160 896
Received on Tue Feb 17 2015 - 11:38:52 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: