From: HUI, Ka Ho <*matthew.hui*>

Date: Mon, 28 Dec 2015 09:27:41 +0000

Dear all,

I am trying to simulate datasets with variable mixing proportion of a mixture of 2 subgroups. Relevant codes are shown below:

$SIMULATION (61965) (24214184 UNIFORM) (3261746 NORMAL) ONLYSIMULATION

$SUBROUTINE ADVAN2

$PK

IF (ICALL.EQ.4.AND.NEWIND.EQ.0) THEN

CALL RANDOM (2,R)

PMIX=R*0.8+0.1 ;SIMUATION OF MIXING PROPORTION in U(0.1,0.9)

CALL RANDOM (2,R)

OMG_ETA1=R*0.4+0.1 ;SIMULATION OF SD OF ETA(1) in U(0.1,0.5)

ENDIF

IF (ICALL.EQ.4.AND.NEWIND.NE.2) THEN

CALL RANDOM (3,R)

CL1_ETA1=R*OMG_ETA1 ;SIMULATION OF RANDOM EFFECT in N(0,OMG_ETA1)

ENDIF

TVCL=THETA(1)

CL=TVCL*(1+CL1_ETA1)

¡K

$MIX

NSPOP=2

P(1)=PMIX

¡ô

P(2)=1-P(1)

¡K

I got the ¡§208 UNDEFINED VARIABLE¡¨ error from this (Location of error shown with an arrow above).

It seems that it does not work if I include a user-defined variable in the $MIX block, nor can I do so in the $OMEGA, $SIGMA or $THETA block. Fortunately somehow I could use the above workaround to allow the simulation of the variance of the random effect CL1_ETA1, instead of relying on the $OMEGA record. But I have no idea how I can simulate different mixing proportions if the above method does not work.

It would be great if somebody can help me a bit on this =]

Best Regards,

Matthew

Received on Mon Dec 28 2015 - 04:27:41 EST

Date: Mon, 28 Dec 2015 09:27:41 +0000

Dear all,

I am trying to simulate datasets with variable mixing proportion of a mixture of 2 subgroups. Relevant codes are shown below:

$SIMULATION (61965) (24214184 UNIFORM) (3261746 NORMAL) ONLYSIMULATION

$SUBROUTINE ADVAN2

$PK

IF (ICALL.EQ.4.AND.NEWIND.EQ.0) THEN

CALL RANDOM (2,R)

PMIX=R*0.8+0.1 ;SIMUATION OF MIXING PROPORTION in U(0.1,0.9)

CALL RANDOM (2,R)

OMG_ETA1=R*0.4+0.1 ;SIMULATION OF SD OF ETA(1) in U(0.1,0.5)

ENDIF

IF (ICALL.EQ.4.AND.NEWIND.NE.2) THEN

CALL RANDOM (3,R)

CL1_ETA1=R*OMG_ETA1 ;SIMULATION OF RANDOM EFFECT in N(0,OMG_ETA1)

ENDIF

TVCL=THETA(1)

CL=TVCL*(1+CL1_ETA1)

¡K

$MIX

NSPOP=2

P(1)=PMIX

¡ô

P(2)=1-P(1)

¡K

I got the ¡§208 UNDEFINED VARIABLE¡¨ error from this (Location of error shown with an arrow above).

It seems that it does not work if I include a user-defined variable in the $MIX block, nor can I do so in the $OMEGA, $SIGMA or $THETA block. Fortunately somehow I could use the above workaround to allow the simulation of the variance of the random effect CL1_ETA1, instead of relying on the $OMEGA record. But I have no idea how I can simulate different mixing proportions if the above method does not work.

It would be great if somebody can help me a bit on this =]

Best Regards,

Matthew

Received on Mon Dec 28 2015 - 04:27:41 EST