NONMEM Users Network Archive

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BAYES method and initial estimate bounds

From: Bill Gillespie <bgillespiester>
Date: Tue, 22 Dec 2015 11:13:45 -0500

Hi all,

If bounds are specified in the $THETA statements for initial estimates,
what, if any, effect do they have when the BAYES method is used?

I initially thought they might work in conjunction with the prior
specifications to implement truncated priors. However that does not seem to
be true because statements like "IF(ABS(THETA(1)) > 10) EXIT 1 14"
sometimes get tripped even when THETA(1) is bounded between -10 and 10 in
the $THETA statement.

Happy Holidays,

Received on Tue Dec 22 2015 - 11:13:45 EST

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