From: Anyue Yin <*anyueyin929*>

Date: Tue, 22 Dec 2015 14:36:09 +0800

Dear all,

I got a problem when using NONMEM with STS method. My aim is to get

individual parameter estimates. I would like to let NONMEM estimate

individual parameter one subject by one subject. My control stream is

partially listed below, which is edited according to this thread

http://www.cognigencorp.com/nonmem/nmo/topic035.html

*$SUBROUTINES ADVAN1 TRANS2*

*$PK*

*CL = THETA(1) * EXP(ETA(1))*

*V = THETA(2) * EXP(ETA(2))*

*S1 = V*

*$ERROR*

*IPRED = F*

* W = F*

* Y = IPRED*(1+EXP(ETA(3))*EPS(1))*

* IRES = DV-IPRED*

*IWRES = IRES/W*

*$THETA*

*(10,20,30) ; CL*

*(10,80,100) ; V*

*$OMEGA*

*100 ; IIV CL*

*100 ; IIV V*

*100 ; IIV SIGMA*

*$SIGMA*

*1 FIXED ; PRO*

*$EST METHOD=1 INTER MAXEVAL=0 NOABORT SIG=3 PRINT=1 POSTHOC*

*$COV*

*$TABLE ID TIME AMT CMT DV PRED IPRED IWRES CL V ETA(1) ETA(2) ETA(3)

ONEHEADER NOPRINT FILE=sdtab101.tab*

The model can run successfully, and I got individual parameter estimates

from output file. I found that for each subject the individual parameter

estimate changed if I change the initial value of THETA. It seems that

NONMEM regarded the initial value fixed (just like a fixed typical value).

But I expected NONMEM to estimate individual parameters based on individual

data rather than the initial value. Is there anything wrong with the code?

Thanks in advance.

Anyue

Received on Tue Dec 22 2015 - 01:36:09 EST

Date: Tue, 22 Dec 2015 14:36:09 +0800

Dear all,

I got a problem when using NONMEM with STS method. My aim is to get

individual parameter estimates. I would like to let NONMEM estimate

individual parameter one subject by one subject. My control stream is

partially listed below, which is edited according to this thread

http://www.cognigencorp.com/nonmem/nmo/topic035.html

*$SUBROUTINES ADVAN1 TRANS2*

*$PK*

*CL = THETA(1) * EXP(ETA(1))*

*V = THETA(2) * EXP(ETA(2))*

*S1 = V*

*$ERROR*

*IPRED = F*

* W = F*

* Y = IPRED*(1+EXP(ETA(3))*EPS(1))*

* IRES = DV-IPRED*

*IWRES = IRES/W*

*$THETA*

*(10,20,30) ; CL*

*(10,80,100) ; V*

*$OMEGA*

*100 ; IIV CL*

*100 ; IIV V*

*100 ; IIV SIGMA*

*$SIGMA*

*1 FIXED ; PRO*

*$EST METHOD=1 INTER MAXEVAL=0 NOABORT SIG=3 PRINT=1 POSTHOC*

*$COV*

*$TABLE ID TIME AMT CMT DV PRED IPRED IWRES CL V ETA(1) ETA(2) ETA(3)

ONEHEADER NOPRINT FILE=sdtab101.tab*

The model can run successfully, and I got individual parameter estimates

from output file. I found that for each subject the individual parameter

estimate changed if I change the initial value of THETA. It seems that

NONMEM regarded the initial value fixed (just like a fixed typical value).

But I expected NONMEM to estimate individual parameters based on individual

data rather than the initial value. Is there anything wrong with the code?

Thanks in advance.

Anyue

Received on Tue Dec 22 2015 - 01:36:09 EST