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From: Abu Helwa, Ahmad Yousef Mohammad - abuay010 <ahmad.abuhelwa >
Date: Mon, 31 Aug 2015 01:18:14 +0000

Dear Nonmem users,

  My question is about ETAPval. I am modelling a parent-metabolite data usi=
ng the 2-stage approach. After modelling the parent drug alone, parameter e=
stimates (for the parent) were fixed in the metabolite model and metabolite=
 parameters were estimated. All ETAPvalules for metabolite parameters were =
acceptable > 0.2 and all metabolite model parameters were estimated precise=
ly; however, some of the ETAPvalues of parent drug parameters became < 0.05=
 while they were acceptable when the parent drug was modelled alone.

Should ETAPvalues for parent parameters stay above the acceptable limit eve=
n if the parameters are fixed or we care only about the ETAPvals for estima=
ted parameters only?

N.B. Simultaneous modelling of the parent-metabolite wasn't possible.

Thank you,

Ahmad Abuhelwa
Email: ahmad.abuhelwa>
Mobile: +61 413118743

Received on Sun Aug 30 2015 - 21:18:14 EDT

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