From: Diane-Charlotte Imbs <*diane.charlotte.imbs*>

Date: Mon, 20 Apr 2015 18:12:34 +0200

Dear nonmem users,

We used the option “-2 RATE” of NONMEM (actual rate of infu=

sion is

unknown): within the control stream:

D1=THETA(1)

Moreover, since several infusions are given to the same patients, we have

added an inter-occasion variability on D1 (see code below)*

We obtained nice fit BUT in the OUTPUT DATA: TIME values corresponding to

blood samples (and DV) are not identical to the actual TIME values of the

INPUT data !?

It seems that NONMEM program adjusts rate values, their interoccasion

variability, and sampling times to have a good fit

*How to fix TIME value corresponding to blood samples ? Indeed, we do not

know the actual infusion rate but we do know the sampling times.*

Can anyone tell me if I chose the right model or help me resolving this?

Thanks in advance,

*$PK

OCC1=0

OCC2=0

IF(DATE.EQ.1) OCC1=1

IF(DATE.EQ.2) OCC2=1

D1=THETA(1)*EXP(ETA(3)+ETA(4)*OCC1+ETA(5)*OCC2)

$THETA (0,168,);D1

$OMEGA .1 ; iiv d1

$OMEGA BLOCK(1) .01 ; iov ETA4 OCC1

$OMEGA BLOCK(1) SAME ; iov ETA5 OCC2

*Loïc FIEVET*

*Interne IPR en pharmacocinétique (1er semestre)*

*Institut Universitaire du Cancer Toulouse - Oncopole*

1 avenue Irène Joliot-Curie

31059 TOULOUSE Cedex 9

Received on Mon Apr 20 2015 - 12:12:34 EDT

Date: Mon, 20 Apr 2015 18:12:34 +0200

Dear nonmem users,

We used the option “-2 RATE” of NONMEM (actual rate of infu=

sion is

unknown): within the control stream:

D1=THETA(1)

Moreover, since several infusions are given to the same patients, we have

added an inter-occasion variability on D1 (see code below)*

We obtained nice fit BUT in the OUTPUT DATA: TIME values corresponding to

blood samples (and DV) are not identical to the actual TIME values of the

INPUT data !?

It seems that NONMEM program adjusts rate values, their interoccasion

variability, and sampling times to have a good fit

*How to fix TIME value corresponding to blood samples ? Indeed, we do not

know the actual infusion rate but we do know the sampling times.*

Can anyone tell me if I chose the right model or help me resolving this?

Thanks in advance,

*$PK

OCC1=0

OCC2=0

IF(DATE.EQ.1) OCC1=1

IF(DATE.EQ.2) OCC2=1

D1=THETA(1)*EXP(ETA(3)+ETA(4)*OCC1+ETA(5)*OCC2)

$THETA (0,168,);D1

$OMEGA .1 ; iiv d1

$OMEGA BLOCK(1) .01 ; iov ETA4 OCC1

$OMEGA BLOCK(1) SAME ; iov ETA5 OCC2

*Loïc FIEVET*

*Interne IPR en pharmacocinétique (1er semestre)*

*Institut Universitaire du Cancer Toulouse - Oncopole*

1 avenue Irène Joliot-Curie

31059 TOULOUSE Cedex 9

Received on Mon Apr 20 2015 - 12:12:34 EDT