Dear Gavin,
Perhaps an idea is to compare the different MATRIX options of the covarianc=
e step of NONMEM, and with the bootstrap, to assess their relative properti=
es.
Erik
________________________________
From: owner-nmusers
of Gavin Jarvis [gej1000
Sent: Saturday, March 29, 2014 5:55 PM
To: nmusers
Subject: [NMusers] NONMEM vs SPSS
Dear NONMEM Users
Does anyone have a view on the relative merits/reliability/accuracy of NONM=
EM ($COV step) vs SPSS (NLR) with respect to their derived values of the pa=
rameter standard errors and parameter correlation matrices?
The data I am analysing are single subject (not population). Parameter esti=
mates from the two programs are, to all intents and purposes, identical. Ho=
wever, the SE values from NONMEM $COV are consistently smaller by 1.5-2.0-f=
old.
Any thoughts?
Gavin
__________________________________________________
Dr Gavin E Jarvis MA PhD VetMB MRCVS
University Lecturer in Veterinary Anatomy
Department of Physiology, Development & Neuroscience
Physiological Laboratory
Downing Street
Cambridge
CB2 3EG
Tel: +44 (0) 1223 333745
Fellow and College Lecturer in Pharmacology
Selwyn College
Cambridge
CB3 9DQ
Tel: +44 (0) 1223 761303
Email: gej1000
Web: www.pdn.cam.ac.uk/staff/jarvis<
http://www.pdn.cam.ac.uk/staff/jarvis>
Twit:
Received on Sat Mar 29 2014 - 13:59:23 EDT
