NONMEM Users Network Archive

Hosted by Cognigen

RE: NONMEM vs SPSS

From: E.Olofsen
Date: Sat, 29 Mar 2014 17:59:23 +0000

Dear Gavin,

Perhaps an idea is to compare the different MATRIX options of the covarianc=
e step of NONMEM, and with the bootstrap, to assess their relative properti=
es.

Erik
________________________________
From: owner-nmusers
 of Gavin Jarvis [gej1000
Sent: Saturday, March 29, 2014 5:55 PM
To: nmusers
Subject: [NMusers] NONMEM vs SPSS

Dear NONMEM Users

Does anyone have a view on the relative merits/reliability/accuracy of NONM=
EM ($COV step) vs SPSS (NLR) with respect to their derived values of the pa=
rameter standard errors and parameter correlation matrices?

The data I am analysing are single subject (not population). Parameter esti=
mates from the two programs are, to all intents and purposes, identical. Ho=
wever, the SE values from NONMEM $COV are consistently smaller by 1.5-2.0-f=
old.

Any thoughts?

Gavin


__________________________________________________
Dr Gavin E Jarvis MA PhD VetMB MRCVS
University Lecturer in Veterinary Anatomy
Department of Physiology, Development & Neuroscience
Physiological Laboratory
Downing Street
Cambridge
CB2 3EG
Tel: +44 (0) 1223 333745

Fellow and College Lecturer in Pharmacology
Selwyn College
Cambridge
CB3 9DQ
Tel: +44 (0) 1223 761303

Email: gej1000
Web: www.pdn.cam.ac.uk/staff/jarvis<http://www.pdn.cam.ac.uk/staff/jarvis>
Twit:


Received on Sat Mar 29 2014 - 13:59:23 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.