NONMEM Users Network Archive

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Re: MU referencing

From: Navin Goyal <navingoyal>
Date: Sun, 26 May 2013 17:46:37 -0400

Hi,
Could we modify the inter-occasion variability example (example. # 7
in the intro7 guide with NM7.1 installation) to inter-group situation
?

MU_1=THETA(1)
TVPAR = EXP(MU_1+ETA(1)) ; fix ETA(1) to a small value ?

GRP0 = EXP(ETA(2))
GRP1 = EXP(ETA(3))

IF (GRP.EQ.0) GRPETA = GRP0
IF (GRP.EQ.1) GRPETA = GRP1

Param = TVPAR*GRPETA


Thanks
Navin Goyal





On Sun, May 26, 2013 at 3:54 PM, Brendan Johnson
<brendan.m.johnson
> Hi all,
>
> When using MU referencing, how do I code the situation where the typical
> value appears to be the same between two groups, but one group is more
> variable how do I give these two groups different ETAs but essentiall=
y the
> same THETA?
>
>
>
> Is this legit?
>
>
>
> tvParam=THETA(.)
>
> MU_1=tvParam
>
> MU_2=tvParam
>
>
>
> Param1=MU_1+ETA(1)
>
> Param2=MU_2+ETA(2)
>
>
>
> Param=Param1*G1+Param2*G2
>
>
>
> Where G1 and G2 equal 0 or 1 based on which group the subject belongs.
>
>
>
> Thanks for the advice,
>
> Brendan



--
Navin Goyal
Received on Sun May 26 2013 - 17:46:37 EDT

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