NONMEM Users Network Archive

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simulation with uncertainty of THETA

From: Ying Zhang <zhyingying>
Date: Mon, 8 Jul 2013 16:18:10 -0400

Dear all,

When do the simulation, if I have all of the parameter information from
literature and internal data, I will fix the PKPD parameter and add about
30% for PK and 40% for PD as IIV. But my question is do we need to think
about the CV% of THETA, since we fixed it, we could not add it in one run.
if it is necessary, for instance, we will add 20% of CV to one mean THETA,
how to do it, or does PsN can implement this issue?

Best
Ying

Received on Mon Jul 08 2013 - 16:18:10 EDT

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